Prevalence, incidence, and prognosis of hepatobiliary disease in community-based patients with type 2 diabetes: the Fremantle Diabetes Study

The Journal of Clinical Endocrinology and Metabolism
Timothy M E DavisWendy A Davis

Abstract

Few studies have examined morbidity and mortality associated with hepatobiliary disease in diabetes. Most have used administrative databases and/or have had limited/incomplete data including recognized risk factors for hepatobiliary disease. The objective of the study was to explore the relationship between type 2 diabetes and hepatobiliary disease in well-characterized patients with detailed risk factor data including viral hepatitis status and hemochromatosis genotype. This was a community-based longitudinal observational study. The study was conducted in an urban Australian community. The study included 1294 patients of mean ± SD aged 64.1 ± 11.3 yr and 5156 age-, gender-, and ZIP code-matched nondiabetic controls. Prevalent and incident hepatobiliary disease and hepatobiliary disease-related death were measured. Competing risks proportional hazard models provided independent associates of these end points. During 13,705 patient-years (mean 11.5 yr), 144 patients had an initial hepatobiliary disease-related hospitalization/cancer registration vs. 403 controls during 63,937 person-years of follow-up, an incidence rate ratio of 1.66 (95% confidence interval 1.37-2.02). Incident hepatobiliary disease was associated with a lower...Continue Reading

Citations

Aug 28, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·George Boon-Bee GohWoon-Puay Koh
May 1, 2012·International Journal of Epidemiology·Timothy M E DavisWendy A Davis
May 8, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuanjie PangZhengming Chen
Oct 2, 2012·International Journal of Molecular Medicine·Xiao-Tao FengQian-Li Tang
Jan 20, 2017·Biomedical Reports·Tatsuki IchikawaKazuhiko Nakao
Jan 15, 2014·Molecular Biology Reports·Xiaotao FengQiuyan Jiang
Jul 14, 2020·Postgraduate Medicine·Harshil ShahWilbert Aronow
Aug 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weishi LiangXiangbo Gou
Aug 18, 2021·Metabolism: Clinical and Experimental·Timothy M E Davis

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