Prevalence, Management, and Long-Term (6-Year) Outcomes of Atrial Fibrillation Among Patients Receiving Drug-Eluting Coronary Stents

JACC. Cardiovascular Interventions
Hyo-In ChoiSeung-Jung Park

Abstract

This study sought to investigate the incidence, management, and clinical relevance of atrial fibrillation (AF) during and after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and evaluate outcomes of different antithrombotic strategies. Uncertainty exists regarding the optimal antithrombotic strategy in patients with AF who are undergoing PCI with DES. Using a consecutive series of 10,027 patients who underwent DES implantation between 2003 and 2011, we evaluated the overall prevalence and clinical impact of AF. In addition, we compared the efficacy and safety of dual antiplatelet therapy (DAPT) (aspirin plus clopidogrel) and triple therapy (DAPT plus warfarin) among patients with AF. The primary outcome was a composite of cardiovascular death, myocardial infarction, or stroke. Overall, 711 (7.1%) patients had a diagnosis of AF at the index PCI. Patients with AF were older, had more comorbid conditions, and more often had a history of strokes; most patients with AF (88.4%) received DAPT rather than triple therapy (10.5%) at discharge. The rate of primary outcome after PCI during the 6-year follow-up period was significantly higher in patients with AF than in those without AF (22.1% vs. 8.0%; p < 0.001)....Continue Reading

Citations

Mar 30, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Yukiko Matsumura-NakanoTakeshi Kimura
Jul 16, 2019·Stroke; a Journal of Cerebral Circulation·Leonardo KnijnikMauricio G Cohen
Nov 11, 2017·European Heart Journal. Cardiovascular Pharmacotherapy·Gorav BatraJonas Oldgren
Nov 8, 2018·Korean Circulation Journal·Boyoung JoungUNKNOWN KHRS Atrial Fibrillation Guideline Working Group
Mar 15, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Despoina-Rafailia BenetouDimitrios Alexopoulos

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