Prevalence of α-thalassaemia genotypes in pregnant women in northern Thailand

The Indian Journal of Medical Research
Somphon PharephanLuksana Makonkawkeyoon

Abstract

Alpha-thalassaemias are genetic disorders with high prevalence in northern Thailand. However, common genotypes and current data on the prevalence of α-thalassaemias have not been reported in this region. Therefore, the objective of the present study was to determine the prevalence of α-thalassaemia genotypes in pregnant women in northern Thailand. Genomic DNA was extracted from blood samples of pregnant women who came to Maharaj Nakorn Chiang Mai University Hospital during July 2009 to 2010. The common deletion and point mutation genotypes of α-thalassaemia were evaluated by gap- polymerase chain reaction (PCR) and PCR with restriction fragment length polymorphism (RFLP). Genotypes of 638 pregnant women were: 409 samples (64.11%) being normal subjects (αα/αα) and 229 samples (35.89%) with α-thalassaemias. these 229 samples could be classified into deletional HbH disease (--SEA/-α3.7) for 18 samples (2.82%); heterozygous α0-thalassaemia --SEA type (--SEA/αα)) for 78 (12.23%); heterozygous α+-thalassaemia - α3.7 type (-α3.7/αα) for 99 (15.52%); homozygous α+-thalassaemia - α3.7 type (-α3.7/- α3.7) for five (0.78%); heterozygous α+-thalassaemia - α4.2 type (-α4.2/αα) for two (0.31%); and heterozygous HbCS (αCSα/αα) for 27 (4.23%) ...Continue Reading

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Citations

Jun 4, 2020·British Journal of Haematology·Suchaya LuewanT Tongsong
Jun 27, 2019·International Journal of Hematology·Kanittha MankhemthongT Sanguansermsri
Jul 15, 2018·International Journal of Hematology·Kesara Nittayaboon, Chamnong Nopparatana
Oct 15, 2020·International Journal of Environmental Research and Public Health·Lucky Poh Wah GohPing-Chin Lee

Related Concepts

Hemoglobin Constant Spring
Hemoglobin H
Abnormal Hemoglobins
Genetic Carriers
Alpha-Thalassemia
Point Mutation
Deletion Mutation
Gene Deletion
Hereditary Diseases
Hospitals, University

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