Prevalence of 4977bp deletion in mitochondrial DNA from patients with chronic kidney disease receiving conservative treatment or hemodialysis in southern Brazil

Renal Failure
Liana Bertolin RossatoElvino José Guardão Barros

Abstract

Damage to mitochondrial DNA (mtDNA) has been described in patients with chronic kidney disease (CKD). The presence of mtDNA 4977bp deletion in many different tissues can serve as a marker of this damage. However, no attempt has been made to detect the presence of mtDNA 4977bp in blood cells of patients with CKD. Polymerase chain reaction techniques (PCR) were used to detect mtDNA 4977bp deletion in blood samples of 94 CKD patients. The prevalence of 4977bp deletion in mtDNA was 73.1% (38/52) in patients with CKD undergoing hemodialysis, 57.1% (27/42) in patients with CKD receiving conservative treatment, and 27.8% (15/54) in control samples (p < 0.001). Higher prevalence of this mutation was not associated with patient age (p = 0.54) or time on hemodialysis (p = 0.70). The higher prevalence of mtDNA 4977bp deletion in patients in this study indicates that the CKD can induce damage to mtDNA in blood cells and could be exacerbated by hemodialysis.

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Citations

Apr 10, 2010·Journal of the American Society of Nephrology : JASN·Eugene P RheeRobert E Gerszten
Jun 18, 2016·Oxidative Medicine and Cellular Longevity·Nicole SchuppAugust Heidland
Oct 13, 2017·Journal of the American Society of Nephrology : JASN·Farsad AfshinniaUNKNOWN Michigan Kidney Translational Core CPROBE Investigator Group
May 13, 2011·Nephron. Clinical Practice·Robert MactierCormac Breen

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