Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series

European Urology
Hendrik IsbarnThomas Steuber

Abstract

The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP. To assess the prevalence of a TGG in a contemporary, consecutive, single-centre RP series and its association with adverse pathology. From January to August 2007, 800 eligible patients (no prior neoadjuvant hormonal therapy) underwent RP for clinically localised prostate cancer (pCA) in our institution. The presence of the third most prevalent Gleason pattern was documented, regardless of whether it was better or worse than the two predominant Gleason grades. The overall prevalence of a TGG was described. Uni- and multivariate logistic regression analyses tested the association between the presence of a TGG <5% versus >or=5% of the whole tumour volume and extracapsular extension (ECE), seminal vesicle invasion (SVI), positive surgical margins (PSM), and lymph node invasion (LNI). Subanalyses were performed to assess the impact of different TGGs at various Gleason scores. A TGG was reported in 180 RP specimens (22.5%). In univariate analysis, the presence of a TGG >/=5% was significantly associated with ECE, SVI, PSM, and LN...Continue Reading

References

Mar 1, 1992·Human Pathology·D F Gleason
Dec 1, 1988·The American Journal of Surgical Pathology·J E McNealT A Stamey
Sep 28, 1998·JAMA : the Journal of the American Medical Association·P C AlbertsenM J Barry
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·D G BostwickJ W Yarbro
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W KattanSteven A Leibel
Apr 24, 2004·The American Journal of Surgical Pathology·Claudio A MosseJonathan I Epstein
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Dec 8, 2005·European Urology·Markus GraefenHartwig Huland
Jan 18, 2006·European Urology·Rodolfo MontironiAldo Bono
May 1, 2007·European Urology·Vincent RaveryLaurent Boccon-Gibod
Dec 14, 2007·The Journal of Urology·Darren E WhittemoreWade J Sexton

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Citations

Jan 15, 2011·Japanese Journal of Clinical Oncology·Katsuyoshi HashineNorihiro Teramoto
Jan 10, 2014·Journal of Clinical Pathology·Kilian M TreurnietTheodorus H Van der Kwast
May 28, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J PastoriF Kleinclauss
Jan 4, 2012·Histopathology·Brett DelahuntHemamali Samaratunga
Apr 7, 2018·Pathology Oncology Research : POR·Sami-Ramzi Leyh-BannurahPierre I Karakiewicz
Aug 8, 2017·Asian Journal of Andrology·Silvia GasparriniRodolfo Montironi
Mar 3, 2019·BJU International·Alberto MartiniAshutosh K Tewari
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jonathan I Epstein
May 28, 2020·The American Journal of Surgical Pathology·Geert J L H van LeendersUNKNOWN ISUP Grading Workshop Panel Members
Sep 6, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Masashi KatoToyonori Tsuzuki
Nov 16, 2016·Prostate Cancer and Prostatic Diseases·W S JangY D Choi
Feb 14, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Satoru TaguchiHiroshi Fukuhara
Jun 27, 2020·Archives of Pathology & Laboratory Medicine·Jonathan I EpsteinKiril Trpkov

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