Prevalence of advanced histological features and synchronous neoplasia in patients with flat adenomas

Gastrointestinal Endoscopy
Vishnu NaravadiAmit Rastogi

Abstract

The prevalence of advanced histology in flat adenomas is uncertain. There are limited data on the prevalence of synchronous adenomas in patients with flat adenomas. The aims of this study were to determine whether the flat adenomas harbor advanced histology more than the polypoid adenomas and whether the presence of flat adenomas is an independent predictor of synchronous adenomas. A retrospective analysis of data from 3 prospective clinical trials conducted at 2 tertiary care referral centers that included patients undergoing screening or surveillance colonoscopy was performed. The location, size, and morphology of each polyp resected was documented and sent for histopathological examination in a unique specimen jar. A total of 2931 polyps were removed in 1340 patients. Of the 1911 adenomas (65.2%), 293 (15.3%) were flat and 1618 (84.7%) were polypoid. The prevalence of advanced histology did not differ between flat and polypoid adenomas (1.4% vs 3.1%; P = .13). Multivariate analysis confirmed that the presence of at least 1 flat adenoma was a predictor of the presence of a large adenoma (P < .01; odds ratio [OR], 2.80; 95% CI, 1.86-4.22), advanced adenoma (P < .01; OR, 2.70; 95% CI, 1.80-4.06), and 3 or more adenomas (P < .01...Continue Reading

References

Jun 20, 2000·Diseases of the Colon and Rectum·M AdachiT Muto
Oct 12, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael J O'brienUNKNOWN National Polyp Study Workgroup
Feb 5, 2005·Diseases of the Colon and Rectum·Makoto OkamotoMasao Omata
Mar 21, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J KimR V Benya
Sep 18, 2014·The Journal of Spinal Cord Medicine

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Citations

Feb 10, 2016·Gastrointestinal Endoscopy·Gottumukkala RajuJohn Stroehlein

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