Prevalence of Advanced, Precancerous Colorectal Neoplasms in Black and White Populations: A Systematic Review and Meta-analysis

Gastroenterology
Thomas F ImperialeThomas W Emmett

Abstract

Colorectal cancer incidence and mortality are higher in black vs white populations. The reasons for these disparities are not clear, yet some guidelines recommend screening black persons for colorectal cancer starting at 40-45 years of age. We performed a systematic review and meta-analysis to compare the prevalence of advanced adenomas (AAs) and advanced precancerous colorectal neoplasms (ACNs) between asymptomatic black and white screen-eligible adults. We searched Ovid MEDLINE, PubMed, Embase, and the Cochrane Library to identify articles (published from 1946 through June 2017) that reported prevalence values of AA or ACN in average-risk black and white individuals undergoing screening colonoscopy. Two authors independently assessed study quality and risk for bias using a modified validated quality assessment instrument. In accord with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 2 authors independently abstracted descriptive and quantitative data from each study. We performed a random-effects meta-analysis to determine risk differences and odds ratios (ORs). Of 1653 articles, we identified 9 studies for analysis that included 302,128 individuals. Six of the 9 studies were of hi...Continue Reading

Citations

Jan 25, 2020·The American Journal of Gastroenterology·Christine L MolmentiJordan J Karlitz
Nov 21, 2019·Digestive Diseases and Sciences·Jose Melendez-RosadoFernando J Castro
May 18, 2019·Current Gastroenterology Reports·Caitlin C Murphy
Jun 12, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David E KearneyMichael A Valente
Nov 5, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carolyn M RutterKathryn E Bouskill
May 19, 2021·JAMA : the Journal of the American Medical Association·Amy B KnudsenIris Lansdorp-Vogelaar
Sep 6, 2020·Cancer Cell·Chen LiRong Zeng
May 29, 2021·Journal of Clinical Gastroenterology·Thomas F ImperialeWalter E Smalley

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