Abstract
Antiretroviral-related adverse drug reactions (ADRs) are one of the leading causes of drug changes, poor adherence, and treatment failure. Therefore, this study was designed to assess the magnitude of ADR and associated factors among pediatric patients on antiretroviral therapy (ART). A retrospective cross-sectional study was conducted by reviewing the medical records of pediatric patients on ART at Hiwot Fana Specialized University Hospital and Jugal Hospital ART clinics. The collected data were coded, entered, and analyzed using SPSS, IBM version 16. The associations of selected categorical variables were done using binary logistic and multivariate logistic regression. Of 186 medical records of pediatric patients on ART, 153 (82.25%) were reviewed. From the total medical records assessed, ADRs were observed in 23 (15.03%) of pediatric patients on ART, of which the most commonly encountered ADRs were anemia (34.8%) and followed by rash (17.4%). Most of ADRs were ranked as grade 3 (39.13%) and followed by grade 2 (30.4%) based on the degree of their severity. The likelihood of developing ADR was significantly associated with the regimen AZT/3TC/NVP (adjusted odds ratio: 6.420; 95% confidence interval: 1.056-39.018) relative to ...Continue Reading
References
Apr 26, 2000·AIDS·A d'Arminio MonforteM Moroni
Feb 5, 2002·Pediatrics·Gwenda VerweelRonald de Groot
Jun 17, 2004·AIDS·UNKNOWN European Paediatric Lipodystrophy Group
Aug 30, 2005·Journal of Tropical Pediatrics·Ira Shah
Oct 13, 2005·AIDS Research and Human Retroviruses·A MocroftUNKNOWN EuroSIDA Study Group
Oct 27, 2005·AIDS·Palmira de F BonoloMark D C Guimarães
Nov 30, 2005·HIV Medicine·C L CooperG Garber
Feb 24, 2006·HIV Medicine·Y YuanU H Iloeje
Apr 28, 2006·Pharmacotherapy·Beulah P SabundayoJoseph B Margolick
Jul 13, 2007·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Cristiane A Menezes de PáduaMark Drew C Guimarães
Jun 6, 2008·AIDS·Job C J CalisImelda Bates
Nov 13, 2008·The Journal of Infectious Diseases·Russell B Van DykeUNKNOWN Pediatric AIDS Clinical Trials Group 219C Team
Dec 9, 2008·BMC Pediatrics·Sibhatu BiadgilignKebede Deribe
Jun 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C DollfusJ Warszawski
Oct 20, 2011·European Journal of Pediatrics·Anita ShetArun S Shet
Feb 16, 2013·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Aboubacar A OumarPaul M Tulkens
Jan 13, 2015·Indian Journal of Pediatrics·Ritu S ParchurePatricia J Emmanuel