Prevalence of alpha-thalassemias in northern Thailand

Human Genetics
M Lemmens-ZygulskaGebhard Flatz

Abstract

The population of northern Thailand has one of the highest frequencies of alpha-thalassemia in the world. However, the available distributional data are controversial. In addition to deletional types of alpha-thalassemia Hb, type Constant Spring should also be taken into consideration in alpha-thalassemia population studies, because it causes clinical alpha-thalassemia in the homozygous state or when present with both alpha-globin genes deleted in trans. We have examined a sample of 215 healthy subjects from four rural districts of Chiang Mai province. Out of these, 77 exhibited anomalies of the alpha-globin genes (alpha alpha/-alpha 3.7 in 36; -alpha 3.7/-alpha 3.7 in 3; -SEA in 30; alpha alpha/alpha CS alpha in 5; alpha alpha alpha anti 3.7 in 3). Therefore, no fewer than 2% of the children in northern Thailand are expected to be born with HbH disease or thalassemic hydrops fetalis. The considerable public health problem of hemoglobinopaties and the increasing acceptance of family planning necessitates facilities for the pre- and postnatal diagnosis of these disorders at the DNA level.

Citations

Dec 11, 1999·Prenatal Diagnosis·Theera TongsongSupatra Sirichotiyakul
Sep 12, 2001·Genetic Testing·F LoreyD H Chui
Dec 14, 2006·Journal of Pediatric Hematology/oncology·Pimlak CharoenkwanTorpong Sanguansermsri
Jul 26, 2012·International Journal of Cell Biology·Rodney P Guttmann, Tamara J Powell
Oct 18, 2005·Acta Haematologica·Sourideth SengchanhGebhard Flatz
Mar 11, 2011·Gynecologic and Obstetric Investigation·K SrisupunditTheera Tongsong
Jul 24, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·S LuewanTheera Tongsong
Jun 1, 2005·Hemoglobin·Pimlak CharoenkwanTorpong Sanguansermsri
Jul 14, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
May 27, 2005·The Journal of Obstetrics and Gynaecology Research·Supatra SirichotiyakulTheera Tongsong
Dec 13, 2005·Annals of the New York Academy of Sciences·David H K Chui
Apr 22, 2004·Journal of Clinical Ultrasound : JCU·Theera Tongsong, Teerapong Tatiyapornkul
Feb 12, 2011·Prenatal Diagnosis·F TongprasertTheera Tongsong
Feb 10, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S LuewanTheera Tongsong
Dec 5, 2009·Prenatal Diagnosis·Sherry Sze Yee HoMahesh Choolani
Aug 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Apr 8, 2016·International Journal of Hematology·Adisak TantiworawitTorpong Sanguansermsri
Jan 23, 2003·Reproductive Biomedicine Online·Wirawit PiyamongkolDagan Wells
Jul 23, 2014·Advances in Hematology·Manit NuinoonUbol Sungyuan
Feb 20, 2013·Blood Cells, Molecules & Diseases·Muhammet Murat CelikHasan Kaya
Jan 29, 2013·Blood·Sant-Rayn PasrichaBeverley-Ann Biggs
Jun 1, 2016·The Indian Journal of Medical Research·Somphon PharephanLuksana Makonkawkeyoon
Aug 12, 2016·Proteomics. Clinical Applications·Pathrapol Lithanatudom, Duncan R Smith
Jan 7, 2017·Blood·Duantida SongdejBHFS International Consortium
Sep 27, 2019·Journal of Immunoassay & Immunochemistry·Lamplaimas TangpanThanusak Tatu
Dec 13, 2006·Clinical Chemistry·Sherry Sze Yee HoMahesh Choolani
Feb 6, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Theera TongsongPharuhas Chanprapaph
Jul 7, 2017·Scientific Reports·Mattapong KulaphisitPathrapol Lithanatudom

Related Concepts

Teens
Genetic Equilibrium
Globin
Genetic Carriers
Alpha-Thalassemia

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

© 2021 Meta ULC. All rights reserved