Prevalence of and detection of resistance to ampicillin and other beta-lactam antibiotics in Haemophilus influenzae in Denmark

Scandinavian Journal of Infectious Diseases
M ArendrupN Frimodt-Møller

Abstract

The susceptibility of Haemophilus influenzae to penicillin V and G, ampicillin and cefuroxime was investigated by MIC, disc and tablet diffusion methods, using chocolate agar as test medium, to determine the prevalence of ampicillin-resistant isolates and the optimal method for their detection. Eighty-six isolates were clinical isolates collected prospectively from July to September 1998 and 22 isolates were clinical isolates with decreased susceptibility to ampicillin previously referred to the reference laboratory. Eighty-seven isolates were ampicillin-susceptible and 16 were ampicillin-resistant. Thirteen produced beta-lactamases. Among the consecutive isolates 12.8% were resistant. With each of the Rosco Neo-sensitabs containing penicillin G, 2.5 microg ampicillin and 33 microg ampicillin, 3 very major errors occurred (resistant isolates misinterpreted as susceptible) and 5-13 major errors (susceptible isolates misinterpreted as resistant). The AB biodisk containing ampicillin (10 microg) was superior to the penicillin V and G discs, i.e. only 1 very major error occurred and major and minor errors were infrequent. The cefuroxime disc identified 4/8 beta-lactamase-negative ampicillin-resistant isolates. Thus, for susceptibil...Continue Reading

References

May 1, 1992·The Journal of Antimicrobial Chemotherapy·M PowellY S Fah
Aug 1, 1990·Antimicrobial Agents and Chemotherapy·P M MendelmanO Onay
May 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G V DoernH Snapper
Mar 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N Frimodt-MøllerB Gahrn-Hansen
Jul 1, 1988·Journal of Clinical Pathology·M Powell, J D Williams
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Aug 1, 1984·Antimicrobial Agents and Chemotherapy·P M MendelmanA L Smith

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Citations

Aug 11, 2004·International Journal of Pediatric Otorhinolaryngology·Hans Ulrik K NielsenNiels Frimodt-Møller

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