Prevalence of and risk factors associated with latent tuberculosis in Singapore: A cross-sectional survey

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Peiling YapCynthia Bin Eng Chee

Abstract

This first cross-sectional survey on latent tuberculosis infection (LTBI) in Singapore was performed by utilizing the QuantiFERON Gold In-tube (QFT-GIT) assay to collect data on the prevalence of LTBI and to identify potential risk factors associated with LTBI. Nationwide household addresses were selected randomly for enumeration, and Singaporeans or Permanent Residents aged 18-79 years were identified. One eligible member per household was selected using the Kish grid. Each participant answered a questionnaire assessing their medical history (including tuberculosis (TB)), socio-economic factors, and lifestyle factors. They also provided a blood specimen for the QFT-GIT assay. Participants with a positive QFT-GIT result were defined as having LTBI if they were asymptomatic. To identify independent risk factors, adjusted hazard ratios were obtained using the multivariable modified Breslow-Cox proportional hazards model. An overall QFT-GIT positivity rate of 12.7% was detected amongst 1682 Singapore residents. There was a wide variation in the positivity rate according to the participants' country of birth. Higher LTBI prevalence was also significantly associated with increasing age, lower educational and socio-economic status, a...Continue Reading

Citations

Jun 22, 2019·The European Respiratory Journal·Adam CohenChristian Wejse
Jan 5, 2019·Journal of Public Health·Benjamin J GrayAnanda Giri Shankar
Jan 27, 2019·BMC Infectious Diseases·James S MoltonNicholas I Paton
Jun 11, 2020·BMC Infectious Diseases·Philip Kam Weng KwanNicholas I Paton
Jul 2, 2020·International Journal of Environmental Research and Public Health·Lisa HermesAnja Schablon
Jun 17, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Gloria Hj ChanRoss A Soo

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