Prevalence of and Risk Factors for Low Free Testosterone Levels in Japanese Men with Well-controlled Human Immunodeficiency Virus Infection.

Current HIV Research
Yusuke YoshinoYasuo Ota

Abstract

The change in the prevalence of hypogonadism with age in men with human immunodeficiency virus (HIV) infection is subject to debate. To address this issue, we diagnosed hypogonadism based on serum levels of free testosterone (fTST) rather than total testosterone which is thought to be an inaccurate indicator. We also determined the relationship between age and fTST levels and identified risk factors for hypogonadism in men with HIV infection. We retrospectively reviewed fTST levels and associated clinical factors in 71 wellcontrolled HIV-infected men who were treated at Teikyo University Hospital between April 2015 and March 2016 and who had data available on serum fTST levels, measured >6 months after starting antiretroviral therapy. fTST was measured using radioimmunoassay on blood samples collected in the morning. Risk factors for hypogonadism were identified using Welch's t-test and multiple regression analysis. The men had a mean (± standard deviation) age of 47.4 ± 13.6 years, and mean (± standard deviation) serum fTST level of 13.0 ± 6.1 pg/mL. Fifteen (21.1%) men had hypogonadism based on a fTST <8.5 pg/mL. Serum fTST levels significantly decreased with age (-0.216 pg/mL/year). Older age and low hemoglobin levels were i...Continue Reading

References

Oct 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A WankeS L Gorbach
Oct 29, 2004·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Teruaki IwamotoHajime Nawata
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Andre B AraujoJohn B McKinlay
Apr 9, 2005·Journal of Endocrinological Investigation·F AziziN Salarkia
Feb 1, 2007·AIDS Patient Care and STDs·Nancy F Crum-CianfloneMark R Wallace
May 3, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Mikio NamikiUNKNOWN Japanese Urological Association/Japanese Society for Study of Aging Male
Jun 4, 2010·International Journal of Clinical Practice·P Dandona, M T Rosenberg
Apr 20, 2011·Nature Reviews. Urology·Ilpo Huhtaniemi, Gianni Forti
Dec 17, 2011·PloS One·Vincenzo RochiraGiovanni Guaraldi
Apr 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Molly M ShoresAlvin M Matsumoto
Oct 26, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eric BachmanShalender Bhasin
Oct 19, 2016·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Yu Seob ShinJong Kwan Park

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