PMID: 6167213Aug 1, 1981Paper

Prevalence of anti-beta-2 microglobulin autoantibodies in sera of rheumatoid arthritis patients with extra-articular manifestations

Annals of the Rheumatic Diseases
A FalusS Bozsóky

Abstract

The frequency and concentration of specific factors binding beta 2 microglobulin were investigated in sera and synovial fluids of patients and in sera of normal controls. High anti-beta 2 m activity was detected in the sera of adult RA patients, particularly in those of with extra-articular disease. Similarly, anti-beta 2 m was present in the synovial fluids of RA but not of osteoarthrosis patients. Both the binding of anti-beta 2 m activity to the Sepharose staphylococcal protein A and its elution position in the second 'IgG' peak after Sephadex G-200 gel filtration suggest the antibody nature of the activity. The possibility of differences not only in titre but also in the specificity of heterologous and homologous anti-beta 2 m antibodies are discussed.

References

Jan 1, 1975·Scandinavian Journal of Immunology·O Ringeén, E Möller
Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·J ShusterM D Poulik
Sep 1, 1976·Arthritis and Rheumatism·M WeisselG Kolarz
Aug 1, 1978·Annals of the Rheumatic Diseases·D ManicourtS Orloff
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D LancetJ L Strominger
Jan 1, 1979·Journal of Immunological Methods·K MereteyS Bozsoky
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonJ B Lindblom
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·P E Evrin, L Wibell

❮ Previous
Next ❯

Citations

Aug 1, 1983·Molecular Immunology·C Vincent, J P Revillard
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergR Hällgren
Aug 1, 1983·European Journal of Cancer & Clinical Oncology·R BatailleJ Sany

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.