PMID: 9440203Jan 24, 1998Paper

Prevalence of antibodies to Borrelia burgdorferi and tick-borne encephalitis virus in an endemic region in southern Germany

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
R KaiserD Neumann-Haefelin

Abstract

With the intention to evaluate the frequency of asymptomatic infections with TBE virus and B. burgdorferi clinical data and serum specimens were collected from 393 individuals living in an area endemic for both agents (Freiburg, southern Germany). Sera were examined by ELISA. Borderline and positive results were checked by immunoblotting. Only specific antibodies detected by immunoblotting (B. burgdorferi: 22 kDa, 31 kDa, 34 kDa, 39 kDa, 83 kDa; TBE: glycoprotein E) were assessed as positive findings. Specific antibodies to B. burgdorferi were detected in 17/105 individuals with possible symptoms of borreliosis (16%) and in 36/288 individuals without current or previous symptoms of borreliosis (12.5%). Antibody to TBE virus was demonstrated in 34/361 individuals (9.4%) without clinical symptoms of TBE or vaccination against TBE. Thirty individuals had been immunised against TBE (10.6%) and two had clinical TBE one year ago. Antibodies against both agents were detected only in 1.5% of all subjects. Considering the low seroprevalence, antibody screening is not recommended prior to TBE vaccination.

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Citations

Aug 16, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I HinterseherH Kuivaniemi
Oct 28, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M DjukicH Schmidt
Mar 17, 2005·Annals of the Rheumatic Diseases·R DinserH Zeidler
Jan 19, 2013·BMC Pulmonary Medicine·Marija DjukicRoland Nau
Apr 9, 2005·Vector Borne and Zoonotic Diseases·W H M van der PoelF H M Borgsteede
May 1, 2015·Clinical and Vaccine Immunology : CVI·Fabian H Weissbach, Hans H Hirsch
Jun 27, 2006·Scandinavian Journal of Infectious Diseases·Yves HansmannDaniel Christmann
May 17, 2014·Scientifica·Helena KuivaniemiGerard Tromp
Apr 17, 2014·Pathogens and Disease·Luwanika MleraMarshall E Bloom
Apr 3, 2019·Pathogens·Wiebke HellenbrandDoris Altmann
Dec 24, 2018·Deutsches Ärzteblatt International·Sebastian RauerRick Dersch

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