Prevalence of antibodies to four human coronaviruses is lower in nasal secretions than in serum

Clinical and Vaccine Immunology : CVI
Geoffrey J GorseTheresa Z O'Connor


Little is known about the prevalence of mucosal antibodies induced by infection with human coronaviruses (HCoV), including HCoV-229E and -OC43 and recently described strains (HCoV-NL63 and -HKU1). By enzyme-linked immunosorbent assay, we measured anti-HCoV IgG antibodies in serum and IgA antibodies in nasal wash specimens collected at seven U.S. sites from 105 adults aged 50 years and older (mean age, 67 ± 9 years) with chronic obstructive pulmonary disease. Most patients (95 [90%]) had at least one more chronic disease. More patients had serum antibody to each HCoV strain (104 [99%] had antibody to HCoV-229E, 105 [100%] had antibody to HCoV-OC43, 103 [98%] had antibody to HCoV-NL63, and 96 [91%] had antibody to HCoV-HKU1) than had antibody to each HCoV strain in nasal wash specimens (12 [11%] had antibody to HCoV-229E, 22 [22%] had antibody to HCoV-OC43, 8 [8%] had antibody to HCoV-NL63, and 31 [31%] had antibody to HCoV-HKU1), respectively (P < 0.0001). The proportions of subjects with IgA antibodies in nasal wash specimens and the geometric mean IgA antibody titers were statistically higher for HCoV-OC43 and -HKU1 than for HCoV-229E and -NL63. A higher proportion of patients with heart disease than not had IgA antibodies to ...Continue Reading


Mar 13, 1975·The New England Journal of Medicine·I Tager, F E Speizer
Oct 1, 1990·Epidemiology and Infection·K A CallowD A Tyrrell
Jun 1, 1981·Infection and Immunity·D C RedfieldL H Kronenberg
Feb 5, 2000·JAMA : the Journal of the American Medical Association·W P GlezenR B Couch
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·S B GreenbergR L Atmar
Jul 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M El-SahlyS B Greenberg
May 10, 2002·The Journal of Infectious Diseases·Ann R FalseyFrederick G Hayden
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Astrid VabretFrançois Freymuth
Dec 19, 2003·The New England Journal of Medicine·Joseph S M PeirisKlaus Stöhr
Mar 23, 2004·Nature Medicine·Lia van der HoekBen Berkhout
Apr 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ron A M FouchierAlbert D M E Osterhaus
Jun 15, 2004·The Journal of Infectious Diseases·Geoffrey J GorsePeter N Peduzzi
Jan 14, 2005·Journal of Medical Virology·Katherine E ArdenIan M Mackay
Jan 19, 2005·The Journal of Infectious Diseases·Nathalie BastienYan Li
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan S ChiuJ S M Peiris
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Aug 17, 2005·Emerging Infectious Diseases·Astrid VabretFrançois Freymuth
Aug 18, 2005·PLoS Medicine·Lia van der HoekKlaus Uberla
Nov 1, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Theo P SlootsIan M Mackay
Nov 4, 2005·The Journal of Infectious Diseases·Patrick C Y WooKwok-Yung Yuen
May 18, 2006·Emerging Infectious Diseases·Frank EsperJeffrey S Kahn
Jun 8, 2006·Journal of Clinical Microbiology·Susanna K P LauKwok-yung Yuen
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jorge GarbinoLaurent Kaiser
Nov 3, 2006·Journal of Virology·Krzysztof PyrcLia van der Hoek
Sep 25, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Xiuping ShaoJeffrey S Kahn
Apr 16, 2008·The Journal of Pediatrics·Heikki RihkanenAnne Pitkäranta
May 23, 2008·Journal of Clinical Microbiology·Ronald DijkmanLia van der Hoek
Feb 26, 2009·The Journal of Infectious Diseases·Geoffrey J GorseKristin L Nichol
May 12, 2009·Nature Reviews. Microbiology·Stanley Perlman, Jason Netland
Feb 2, 2010·Emerging Infectious Diseases·Nicola PrincipiSusanna Esposito

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