Prevalence of antibodies to hepatitis E virus among Japanese blood donors: identification of three blood donors infected with a genotype 3 hepatitis E virus

Journal of Medical Virology
Satoko FukudaHiroaki Okamoto

Abstract

Risk factors for acquiring hepatitis E among individuals in industrialized countries including Japan are not fully understood. We investigated whether Japanese blood donors with or without an elevated alanine aminotransferase (ALT) level are likely to have hepatitis E virus (HEV) infection. Serum samples were collected from 5,343 voluntary blood donors including 1,087 donors with elevated ALT of 61-966 IU/L and 4,256 donors with normal ALT (< or = 60 IU/L) at two Japanese Red Cross Blood Centers, and were tested for the presence of anti-HEV IgG by in-house enzyme-linked immunosorbent assay (ELISA). Overall, 200 donors (3.7%) were positive for anti-HEV IgG, including 32 (2.9%) with elevated ALT and 168 (3.9%) with normal ALT. Serum samples with anti-HEV IgG were further tested for the presence of anti-HEV IgM by in-house ELISA and for HEV RNA by reverse transcription (RT)-polymerase chain reaction (PCR). Three donors with ALT of 966, 62 or 61 IU/L were positive for anti-HEV IgM and HEV RNA. The HEV isolates obtained from the three viremic donors segregated into genotype 3, were 91.5-93.4% similar to each other in the 412 nucleotide sequence of open reading frame 2, and had the highest identity of 91.5-94.9% with the JRA1 isolate...Continue Reading

References

Sep 1, 1995·The American Journal of Tropical Medicine and Hygiene·E T ClaysonM P Shrestha
Aug 1, 1996·Computer Applications in the Biosciences : CABIOS·R D Page
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·X J MengS U Emerson
Feb 6, 1999·The Journal of General Virology·Y WangT J Harrison
Jul 8, 1999·Liver·T J Harrison
Sep 29, 1999·Veterinary Microbiology·J D ChandlerD A Anderson
Dec 22, 1999·Journal of Viral Hepatitis·V A Arankalle, L P Chobe
Apr 20, 2001·Journal of Food Protection·J L Smith
Sep 6, 2001·Journal of Medical Virology·G G Schlauder, I K Mushahwar
Dec 14, 2001·Biochemical and Biophysical Research Communications·H OkamotoA Yoshikawa
Dec 19, 2001·Emerging Infectious Diseases·W H van der PoelA M de Roda Husman
Feb 22, 2002·Journal of Medical Virology·Jaw-Ching WuXiang-Jin Meng
Feb 28, 2002·Journal of Hepatology·Vidya A ArankalleAtul M Walimbe
May 10, 2002·The Journal of Infectious Diseases·Kazuaki TakahashiShunji Mishiro
Jul 13, 2002·Journal of Medical Virology·You-Chun WangTim J Harrison
Aug 31, 2002·Journal of Clinical Microbiology·Hitoshi MizuoHiroaki Okamoto
Oct 31, 2002·The Journal of Infectious Diseases·Tatsuya AikawaHiroaki Okamoto
Nov 1, 2002·Journal of Clinical Microbiology·Yanlong Pei, Dongwan Yoo
Nov 1, 2002·The New England Journal of Medicine·Kazuyuki SuzukiHiroaki Okamoto
May 13, 2003·Reviews in Medical Virology·Suzanne U Emerson, Robert H Purcell
Jul 10, 2003·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akiko KunoHiroaki Okamoto
Aug 9, 2003·Lancet·Shuchin TeiShunji Mishiro
Sep 10, 2003·The Journal of Infectious Diseases·Hiroyuki MatsudaShunji Mishiro
Dec 23, 2003·Internal Medicine·Hiroaki OkamotoTsutomu Nishizawa
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Joseph Felsenstein

❮ Previous
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Citations

Jan 11, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Arbeitskreis Blut des Bundesministeriums für Gesundheit
Jun 30, 2005·Animal Health Research Reviews·S Denise Goens, Michael L Perdue
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Georg PauliCarl-Heinz Wirsing von König
Mar 1, 2008·Intervirology·Hidenori ToyodaJunki Takamatsu
Dec 30, 2015·Nature Reviews. Neurology·Harry R DaltonBart C Jacobs
Mar 30, 2011·Virus Research·Tatsuo Miyamura
Nov 11, 2008·The Lancet Infectious Diseases·Harry R DaltonMalcolm Banks
Apr 21, 2006·Transfusion Medicine·E BoxallC-G Teo
Jan 25, 2007·Journal of Viral Hepatitis·M HerremansM P G Koopmans
Jun 1, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaharu Takahashi, Hiroaki Okamoto
Dec 24, 2009·Journal of Medical Virology·Masaharu TakahashiHiroaki Okamoto
Dec 17, 2008·Journal of Hepatology·Florian Bihl, Francesco Negro
Dec 8, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mohammad Ali AssarehzadeganS A Rahim Rezaee
Sep 23, 2016·Viruses·Mohammad S KhurooNaira S Khuroo
Jun 26, 2017·Practical Neurology·Brendan N McleanHarry R Dalton
Nov 21, 2017·Nature Reviews. Disease Primers·Nassim KamarHarry R Dalton
Aug 19, 2017·The American Journal of Tropical Medicine and Hygiene·Hossain M S SazzadEmily S Gurley
Aug 31, 2006·Current Opinion in Infectious Diseases·Chong Gee Teo
Oct 5, 2016·Middle East Journal of Digestive Diseases·Meysam BehzadifarMasoud Behzadifar
Sep 10, 2016·World Journal of Gastroenterology : WJG·Mohammad S KhurooNaira S Khuroo
Nov 26, 2011·Expert Review of Anti-infective Therapy·Kenrad E NelsonAlain B Labrique
Jun 29, 2006·World Journal of Gastroenterology : WJG·De-Ying TianNing-Shao Xia
Feb 8, 2020·Vox Sanguinis·Amit GoelRakesh Aggarwal
Nov 29, 2011·Indian Journal of Medical Microbiology·M Bajpai, E Gupta
Sep 4, 2021·Journal of Multidisciplinary Healthcare·Reem A Al DossaryKhaled R Alkharsah

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