Prevalence of antiseptic-resistance genes in staphylococci isolated from orthokeratology lens and spectacle wearers in Hong Kong

Investigative Ophthalmology & Visual Science
Guang-sen ShiPauline Cho

Abstract

To compare isolation of staphylococci from periorbital tissues and accessories of orthokeratology (ortho-k) lens and spectacle wearers and investigate prevalence of antiseptic-resistance (QAC) genes. To determine minimum inhibitory concentrations (MIC) of antiseptics and antibiotic susceptibility of isolates. Staphylococci were isolated from eyelids, eyelashes, and conjunctival sacs of 23 ortho-k lens wearers and 20 spectacle wearers. Samples were also collected from ortho-k lenses, lens cases, and spectacle frames. Isolations of Staphylococcus aureus were compared between ortho-k subjects and controls for all samples and for coagulase-negative staphylococci (CNS) from conjunctival sacs. QAC genes were amplified in 110 S. aureus and 59 CNS isolates and prevalence compared in isolates from ortho-k lens and spectacle wearers. Associations were assessed between presence of QAC genes and antibiotic and antiseptic susceptibility. Although isolation of S. aureus did not differ significantly in periorbital samples from ortho-k and control subjects, QAC genes were significantly more common in both S. aureus and CNS from ortho-k subjects (odds ratio 4.4 and 10.74, respectively). Overall, qacA/B was the predominant gene detected, being p...Continue Reading

Associated Clinical Trials

Citations

Jan 23, 2016·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Rasha H BassyouniEman Mostafa
Mar 20, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Shi Guang-SenPauline Cho
Aug 5, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Maureen BoostZhaoran Wang
Feb 7, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Sin Wan CheungPauline Cho
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Stephen J VincentLyndon Jones

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