Prevalence of atheromatous and non-atheromatous cardiovascular disease by age in chronic kidney disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Cédric VillainZ Massy

Abstract

Although chronic kidney disease (CKD) and age are major risk factors for cardiovascular disease (CVD), little is known about the relative proportions of atheromatous and non-atheromatous CVD by age in CKD patients. We used baseline data from the French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort of 3033 patients (65% men) with CKD Stages 3-4 to study crude and adjusted associations between age, the estimated glomerular filtration rate (eGFR), atheromatous CVD (coronary artery disease, peripheral artery disease and stroke) and non-atheromatous CVD (heart failure, cardiac arrhythmia and valvular heart disease). Mean age was 66.8 and mean Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR was 32.9 mL/min/1.73 m2. In the <65, (65-74), (75-84) and ≥85 year age groups, the prevalence was, respectively, 18.7, 35.5, 42.9 and 37.8% for atheromatous CVD, and 14.9, 28.4, 38.1 and 56.4% for non-atheromatous CVD. After adjusting for albuminuria, sex and CVD risk factors, the odds ratio (OR) [95% confidence interval (CI)] for (65-74), (75-84) and ≥85 age groups (compared with the <65 group) was, respectively, 1.99 (1.61-2.46), 2.89 (2.30-3.62), 2.72 (1.77-4.18) for atheromatous CVD and 2....Continue Reading

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Citations

Apr 9, 2020·International Journal of Molecular Sciences·Camélia MakhloufiStéphane Poitevin
Apr 9, 2020·Toxins·Guillaume LanoMarion Sallée
Apr 17, 2020·Clinical Kidney Journal·Cédric VillainZiad A Massy
Jun 4, 2021·Clinical and Translational Science·Solène M LavilleUNKNOWN CKD-REIN Study Collaborators
Aug 26, 2021·Clinical Kidney Journal·Matthieu GiotGuillaume Lano

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