Prevalence of autoimmune diseases and clinical significance of autoantibody profile: Data from National Institute of Hygiene in Rabat, Morocco

Human Immunology
Hakima MissoumYoussef Bakri

Abstract

The objective of this study was to explore the prevalence of various autoimmune diseases (AIDs) in a large cohort of patients and to characterize the autoantibody profile in the patients with and without AIDs to confirm the diagnosis and to refine the Moroccan databases. Retrospective study was conducted in the Laboratory of autoimmunity National Institute of Hygiene (NIH) of Rabat in Morocco. A total of 3182 consecutive Moroccan patients (2183 females and 999 males) whose sera were tested for 14 autoantibody profile between 2010 and 2016. Only 944 (29.7%) patients were diagnosed with AIDs of those suspected. The prevalence of systemic lupus erythematosus (SLE), intestinal malabsorption (IM) and arthritis polyarthralgia (AP) were the highest (4.2, 4.1 and 4%), subsequently followed by rheumatoid arthritis (RA) (2.8%), cholestatic syndrome (CS) (1.8%), interstitial lung disease (ILD) (1.6%).In females IM, AP and SLE also showed the highest prevalence (5.4%, 5.3% and 4.9% respectively), while of male, SLE showed the highest prevalence (1.9%). The prevalence of ANA was increased in most patients with systemic especially in neuropathy (NP), hemolytic anemia (HA), primary Sjogren's syndrome (pSS), dermatomyositis (DM), thrombocytope...Continue Reading

Citations

Mar 7, 2021·Antibodies·Irina A PashninaValeriy A Chereshnev
May 5, 2021·Diabetes Research and Clinical Practice·Dimitrios GougourelasKyriaki Athina Karavanaki
May 22, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yeison Santamaria-Alza, Gloria Vasquez
Jul 6, 2021·Indian Journal of Clinical Biochemistry : IJCB·Prishni GuptaEli Mohapatra
Jul 6, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Tej I MehtaJames H Tabibian
Jul 6, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Linnea HaggårdJonas F Ludvigsson
Dec 24, 2021·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Mickael EssoumaEric Hachulla

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