Prevalence of beta-thalassemia trait in premarital screening in Al-Hassa, Saudi Arabia

Annals of Saudi Medicine
Ahmad Al-Suliman

Abstract

The Al-Hassa area is one of the regions in Saudi Arabia where hemoglobinopathies are prevalent. The Saudi Ministry Of Heath designed a protocol for premarital testing after the royal decree in December 2003. The protocol was implemented in a February 2004 order. The aim of this study was to determine the prevalence of beta-thalassemia trait among subjects coming for premarital screening in the Al-Hassa area. From February 2004 to November 2004, healthy subjects coming to six marriages consultation centers in the Al-Hassa area underwent routine mandatory tests. Subjects were considered to have beta-thalassemia trait if they had a mean corpuscular volume (MCV) <80 fL and/or a mean corpuscular hemoglobin (MCH) <27 pg and a hemoglobin A2 level >3.2%. Venous blood was taken into an EDTA tube and the complete blood count and red blood cell indices were measured by a Coulter automated cell counter on the same day of hemoglobin collection. Electrophoresis was done on cellulose acetate. All Saudi participants (n=8918), including 4218 (47.3%) males and 4700 (52.7%) females were screened. The prevalence of beta-thassemia trait with high hemoglobin A2 and microcytic hypochromic anemia was 3.4% (307/8918). In countries with a high prevalenc...Continue Reading

References

Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Feb 13, 2003·Pediatric Clinics of North America·Louise Lo, Sylvia Titi Singer

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Citations

Mar 20, 2016·Journal of Medical Screening·Alireza MoafiHadi Moafi
Dec 12, 2012·Journal of Community Genetics·Hanan A Hamamy, Nasir A S Al-Allawi
Feb 1, 2018·Current Medical Research and Opinion·Amani M Al-AmodiJ Francis Borgio
Apr 9, 2008·Journal of Pediatric Hematology/oncology·Mehran Karimi, Nima Jamalian
Sep 29, 2009·Journal of Clinical Pathology·M T H AshtianiM Alam
Sep 21, 2013·Orphanet Journal of Rare Diseases·Mohamad H QariShaker A Mousa
Feb 23, 2011·Journal of Infection and Public Health·Nahla Khamis Ragab IbrahimWaleed Milaat

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Methods Mentioned

BETA
electrophoresis

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