Prevalence of bilateral partial seizure foci and implications for electroencephalographic telemetry monitoring and epilepsy surgery

Electroencephalography and Clinical Neurophysiology
D Blum

Abstract

Most patients with partial seizures of temporolimbic onset have predominantly unilateral seizure foci, which partly accounts for the success of unilateral temporal lobectomy. The prevalence of bilateral foci is not known. "Discordant" seizures are those which arise from the contralateral side from the usual focus. "Concordance" is the fraction of seizures which arise from the majority side, ranging from 0.5 to 1.0. From observations of seizures recorded in an epilepsy monitoring unit, a model of the patient population can be determined by non-linear least squares methods. Six hundred and five seizures from 57 consecutive patients with non-lesional temporolimbic epilepsy were studied. In the model population, 15% of patients have concordance of less than 70%, and 80% have concordance > 90%. Using Bayes' theorem, the observation of 5 concordant seizures implies a 95% chance of the patient having a concordance of at least 90%. If one discordant seizure is recorded, then to reach the 95% confidence level of 90% concordance requires a total of 11 concordant seizures. For the smaller group of patients with strictly unilateral interictal spikes, only 4 concordant seizures need to be recorded to achieve the same level of confidence of ...Continue Reading

Citations

Apr 30, 1998·Journal of Magnetic Resonance Imaging : JMRI·Y Y Sitoh, R D Tien
Jun 14, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Dean P SarcoJoseph R Madsen
Mar 1, 2003·Epilepsy & Behavior : E&B·Donald M. Olson
Mar 10, 2000·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·E L SoB P Mullan
Feb 20, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Giridhar P KalamangalamWilliam M Bingaman
Jun 24, 1998·Epilepsia·D E BlumR S Fisher
Feb 14, 2007·Epilepsia·Demetrios VelisUNKNOWN ILAE DMC Subcommittee on Neurophysiology
Jul 10, 2002·Epilepsia·Sheryl R HautSusan Spencer
Jul 30, 2015·Epilepsia·Aaron F StruckM Brandon Westover
Oct 26, 2005·Epilepsy & Behavior : E&B·Sheryl R Haut
Feb 25, 2014·Epilepsy Research·Wonsuk KimJohn C Oakley
Oct 7, 2006·Seizure : the Journal of the British Epilepsy Association·Eun Jung ChoiSang Ahm Lee
Jun 4, 2013·Seizure : the Journal of the British Epilepsy Association·Chellamani HariniSanjeev V Kothare
Sep 2, 2016·Epilepsy Currents·Barbara C Jobst
Jun 1, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M Sadler, R Desbiens
Aug 21, 2010·Clinical EEG and Neuroscience·M TripathiP S Chandra
Aug 21, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mohammed M JanSusan R Rahey
Feb 13, 2014·Experimental and Therapeutic Medicine·Kang YangJian Yin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.