Prevalence of bone loss in a population with cystic fibrosis

British Journal of Nursing : BJN
Julie Robertson, Kath Macdonald

Abstract

The adverse effect of an increased life expectancy for people with cystic fibrosis (CF) is the increased risk of complications, such as CF-related low bone mineral density (BMD). Diagnosis of CF-related low BMD is confirmed by a dual-energy X-ray absorptiometry (DXA) scan. This study reports the results of an audit of DXA scans in 108 adults with CF in our clinic. The most common risk factors for bone loss were vitamin D deficiency (89%), CF-related diabetes (53%), low body mass index (39%) and post-lung transplant (25%); half of those with bone loss were genotype homozygous DF508. Overall fracture incidence was 5.5%; low BMD was not associated with high fracture rates. Thus BMD may not be a good predictor of fracture risk. Treatment includes bisphosphonates, which are difficult to take and have uncertain long-term effects. It is unknown whether bisphosphonate therapy is justified in this already overburdened group.

References

Nov 1, 1996·Calcified Tissue International·R A FaulknerA A Wilkinson
Nov 2, 1996·BMJ : British Medical Journal·S M Sawyer
Jul 11, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S L ElkinM E Hodson
Sep 24, 2002·Archives of Disease in Childhood·I M van der SluisS M P F de Muinck Keizer-Schrama
Oct 18, 2003·American Journal of Respiratory and Critical Care Medicine·Robert M ArisDavid A Ontjes
Oct 29, 2004·Current Opinion in Pulmonary Medicine·Robert ArisDavid Ontjes
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Robert M ArisTerry B White
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Michael P BoyleNoah Lechtzin
May 6, 2006·American Journal of Respiratory and Critical Care Medicine·Elizabeth F SheadJuliet E Compston
Dec 15, 2006·Chest·Anna Silvia NeriMaria Luisa Brandi
Dec 17, 2008·Journal of Paediatrics and Child Health·Konstantinos DourosStavros Doudounakis

❮ Previous
Next ❯

Citations

Mar 24, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·H von der HardtG Ullrich
Jan 7, 2011·Journal of Osteoporosis·Ashwini P GoreAntine E Stenbit
Nov 28, 2013·Advances in Medical Sciences·J AmbroszkiewiczT Laskowska-Klita
Jun 12, 2014·Revista da Associação Médica Brasileira·Roberta VanacorTânia W Furlanetto
Feb 8, 2013·International Journal of Pediatric Endocrinology·Lisa Swartz ToporCatherine M Gordon
Feb 23, 2018·Current Allergy and Asthma Reports·Joseph M Carrington, Jill A Poole
May 1, 2012·Biological Research for Nursing·Maria J Lopez-RodriguezJuan D Pedrera-Zamorano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Pulmonary Medicine
Charles S Haworth
Diabetic Medicine : a Journal of the British Diabetic Association
A I AdlerD Bilton
Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Jessica Cemlyn-Jones, Fernanda Gamboa
Paediatric Respiratory Reviews
Isabelle Sermet-GaudelusRobert M Aris
American Journal of Respiratory and Critical Care Medicine
Bradley S QuonChristopher H Goss
© 2021 Meta ULC. All rights reserved