Prevalence of C-reactive protein elevation and time course of normalization in acute pericarditis: implications for the diagnosis, therapy, and prognosis of pericarditis

Circulation
Massimo ImazioRita Trinchero

Abstract

The role of inflammatory markers is not well defined for either diagnosis or treatment of pericarditis. The aim of this study is to prospectively evaluate the frequency of high-sensitivity C-reactive protein (hs-CRP) elevation in patients with acute pericarditis, its time course of normalization, and the possible importance for diagnosis, therapy, and prognosis. Two hundred consecutive patients with viral or idiopathic acute pericarditis (mean age, 53 ± 15.5 years; 103 men) were studied from August 2005 to August 2007 in 2 Italian referral centers. Hs-CRP was determined at presentation and then every week until normalization. Hs-CRP elevation was recorded in 156 of 200 cases (78%) at presentation. Recognized causes of a negative hs-CRP at presentation were early assessment in 15 of 44 cases (34%) and previous anti-inflammatory therapies in 22 of 44 cases (50%). Hs-CRP normalization was achieved with the following time course: 120 of 200 (60%) at week 1, 170 of 200 (85%) at week 2, 190 of 200 (95%) at week 3, and all cases (100%) at week 4. In multivariable analysis, incomplete response to empirical anti-inflammatory therapy at week 1 (hazard ratio, 2.98; 95% confidence interval, 1.80 to 4.94; P < 0.001), corticosteroid therapy ...Continue Reading

References

Mar 8, 2003·JAMA : the Journal of the American Medical Association·David H Spodick
May 4, 2004·European Heart Journal·Bernhard MaischUNKNOWN Task Force on the Diagnosis and Management of Pricardial Diseases of the European Society of Cardiology
Nov 19, 2004·The New England Journal of Medicine·Richard A Lange, L David Hillis
Mar 29, 2006·Circulation·William C Little, Gregory L Freeman
May 16, 2007·Circulation·Massimo ImazioRita Trinchero
Aug 19, 2007·Journal of Cardiovascular Medicine·Massimo ImazioRita Trinchero
Jan 24, 2008·Nature Clinical Practice. Cardiovascular Medicine·Massimo ImazioYehuda Adler
Jan 29, 2008·International Journal of Cardiology·Massimo Imazio, Rita Trinchero
Mar 6, 2009·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Massimo ImazioYehuda Adler
Oct 28, 2009·Nature Reviews. Cardiology·Massimo ImazioYehuda Adler
Jan 30, 2010·Progress in Cardiovascular Diseases·Lori A Blauwet, Leslie T Cooper
Feb 24, 2010·Circulation·Massimo ImazioYehuda Adler
Aug 26, 2010·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler

❮ Previous
Next ❯

Citations

May 3, 2011·Current Infectious Disease Reports·Massimo Imazio
Apr 11, 2012·Current Opinion in Pulmonary Medicine·Massimo Imazio
Apr 30, 2014·Revista Española De Cardiología·Massimo Imazio
Mar 28, 2012·Current Opinion in Cardiology·Massimo Imazio
Sep 22, 2011·Expert Review of Cardiovascular Therapy·Massimo Imazio
Oct 27, 2012·Expert Review of Cardiovascular Therapy·Massimo Imazio
Apr 10, 2015·Heart·Massimo Imazio, Fiorenzo Gaita
Aug 12, 2015·Nature Reviews. Cardiology·Massimo ImazioFiorenzo Gaita
Aug 4, 2012·Medical Hypotheses·Ziad KhoueiryFrançois Roubille
Aug 14, 2012·Autoimmunity Reviews·Silvia MaestroniAntonio Brucato
Feb 1, 2012·Current Problems in Cardiology·David M DudzinskiJudy W Hung
Mar 24, 2016·Current Cardiology Reports·Alexander FardmanYehuda Adler
Aug 8, 2015·Journal of the Royal Army Medical Corps·Andrew T CoxS Ray
Jan 30, 2015·Pharmacotherapy·Nicholas C SchwierShivdev K Rao
May 3, 2016·Journal of Psychiatric Research·Hunter M GibbsRicardo Cáceda
May 24, 2015·Cardiac Electrophysiology Clinics·A John BaksiSanjay K Prasad
Jan 26, 2016·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Apr 11, 2015·Case Reports in Medicine·Toufik Mahfood HaddadAryan N Mooss
Feb 4, 2014·International Journal of Cardiology·Panagiotis VasileiouDimitrios Vassilopoulos
Oct 9, 2012·International Journal of Cardiology·Massimo Imazio, Brian D Hoit
Sep 29, 2011·Archives of Cardiovascular Diseases·Philippe Meurin, Jean-Yves Tabet
Sep 28, 2013·Archives of Cardiovascular Diseases·François RoubilleJean-Claude Tardif
Apr 25, 2016·Current Cardiology Reports·Massimo ImazioPhilippe Charron
Dec 18, 2014·The New England Journal of Medicine·Martin M LeWinter
Jul 29, 2016·Journal of Cardiovascular Medicine·Massimo ImazioAlberto Martini
Dec 28, 2007·Atherosclerosis·William S HarrisErnst J Schaefer
Oct 12, 2016·Progress in Cardiovascular Diseases·Massimo ImazioFiorenzo Gaita
Dec 9, 2016·European Journal of Clinical Investigation·George LazarosDimitris Tousoulis
May 26, 2016·European Heart Journal. Acute Cardiovascular Care·Toru SuzukiEduardo Bossone
Jun 25, 2015·Revista da Associação Médica Brasileira·Márcio ToniniFábio Fernandes
Aug 17, 2011·Circulation·Massimo ImazioYehuda Adler
Nov 12, 2019·Expert Review of Cardiovascular Therapy·Alessandro AndreisGaetano Maria de Ferrari
Dec 14, 2019·JAAPA : Official Journal of the American Academy of Physician Assistants·Nicholas C SchwierTaylor M Epperson
Jan 31, 2020·Advanced Emergency Nursing Journal·Nicholas C SchwierGrant H Skrepnek
May 14, 2020·Journal of Cardiovascular Pharmacology·George F WohlfordAntonio Abbate
May 22, 2017·Current Cardiology Reports·Bo XuPaul C Cremer
Nov 21, 2019·The Annals of Pharmacotherapy·Nicholas C Schwier, Katherine O'Neal
Dec 28, 2019·JAAPA : Official Journal of the American Academy of Physician Assistants·Nicholas C SchwierTaylor M Epperson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.