Prevalence of CD8+ cytotoxic lymphocytes in human neoplasms

Cellular Oncology (Dordrecht)
Niclas C BlessinAndrea Hinsch

Abstract

Immune checkpoint inhibitors have recently been approved by the US FDA as first and/or second line therapy in a subset of cancer types. Recent evidence suggests that the quantity of tumor infiltrating lymphocytes (TILs) influences the likelihood of response to immune checkpoint inhibitors. Here, we set out to assess the density of CD8+ lymphocytes in a wide range of different cancer types and subtypes. The density of CD8+ lymphocytes was compared across different cancer types using tissue microarrays (TMAs) composed of up to 50 tumor samples each from 84 different cancer types and subtypes. In total 2652 cancers and 608 normal tissues were successfully analyzed by CD8 immunohistochemistry followed by automated image analysis of digitized slides. We found that the median CD8+ lymphocyte counts ranged from 6 cells/mm2 in pleomorphic adenoma up to 1573 cells/mm2 in Hodgkin's lymphoma. The CD8 counts were generally lower in normal tissues compared to cancer tissues. Blood vessels of the spleen were the only non-lymphatic tissue staining positive for CD8. Tumor types approved for checkpoint inhibitor therapy, including malignant melanoma (81), muscle invasive urothelial carcinoma (119), small cell lung cancer (120), clear cell renal...Continue Reading

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Citations

Apr 18, 2021·Cellular Oncology (Dordrecht)·Niclas C BlessinStefan Steurer
Nov 7, 2020·The American Journal of Dermatopathology·Paul B GoogeJuneko E Grilley-Olson
Aug 13, 2021·Frontiers in Oncology·Dengqiang WuSufang Zhou
Aug 28, 2021·International Journal of Molecular Sciences·Laura GehrckenJan Dörrie
Jun 4, 2021·The American Journal of Surgical Pathology·Luisa LorenziFabio Facchetti

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Clinical Trials Mentioned

NCT02488759
NCT02584829
NCT02196961
NCT03271372

Software Mentioned

HALO
R
JMP Pro

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