PMID: 16514380Mar 4, 2006Paper

Prevalence of celiac disease in Tunisian blood donors

Gastroentérologie Clinique Et Biologique
Fethia BdiouiHamouda Saffar

Abstract

Prevalence of adult celiac disease is unknown in Tunisia. Symptomatic forms are less frequent than silent forms, which, according to recent serological screening in Europe and the United States, have an estimated prevalence of 1/100 to 1/500. We aimed to determine the prevalence of celiac disease in healthy blood donors in Tunisia. Between November 2002 and March 2004, 1 418 sera from blood donors were tested for IgA anti-endomysium antibodies (EMA) by indirect immuno-fluorescence on monkey esophagus cryosections. The sample population included 1090 men and 328 women: mean age 29 and 26 years respectively. Three sera from two men and one woman were positive for IgA EMA. ELISA search for anti-tissue tranglutaminase antibodies (ATG) in these three sera was positive in two. Upper gastrointestinal endoscopy with proximal intestinal biopsies was performed in the three patients. Subtotal or total villous atrophy was observed in the two ATG-positive patients, confirming the diagnosis of celiac disease. In the third patient, histologic examination did not show any abnormality. Adult celiac disease is considered relatively rare in Tunisia. In fact, our study revealed a prevalence of about 1/700 among blood donors.

References

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Citations

Mar 25, 2010·World Journal of Gastroenterology : WJG·Kassem BaradaPeter Green
Dec 17, 2011·World Journal of Gastroenterology : WJG·Luigi GrecoSelma Terzic
May 16, 2013·World Journal of Gastroenterology : WJG·Wolfgang KratzerMark H Haenle
Jul 5, 2008·Digestive Diseases and Sciences·Gudmundur F JohannssonVigfus Thorsteinsson
Jun 21, 2013·Alimentary Pharmacology & Therapeutics·J Y KangK Y Ho
Jul 26, 2013·Immunological Investigations·Mongi Ben HarizSondès Makni
Dec 1, 2007·European Journal of Gastroenterology & Hepatology·Violeta RokaAnastasios E Germenis
Oct 5, 2010·Annals of Medicine·Federico BiagiGino Roberto Corazza
Jun 30, 2021·Critical Reviews in Food Science and Nutrition·Vijole BradauskieneCarlo Catassi

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