PMID: 7020444May 1, 1981Paper

Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon

The American Journal of Tropical Medicine and Hygiene
J J FerraroniM Suzuki

Abstract

The prevalence of chloroquine-resistant falciparum malaria was determined for humans living at 28 different sites in the Brazilian Amazon. Blood samples obtained from each patient were defibrinated, placed in vials containing 0.5% glucose and or chloroquine and incubated for 24 hours at 39-40 degrees C without agitation. In vitro sensitivity of the parasite to four different concentrations of chloroquine was determined for each sample. After 24 hours of incubation, trophozoites of Plasmodium falciparum developed to schizonts in all control cultures (no chloroquine) as well as in 80.6, 48.4, 11.8 and 7.5% of the cultures containing 0.5, 1.0, 2.0, and 3.0 nmol chloroquine/ml blood, respectively. Chloroquine-resistant P. falciparum was found in blood samples from all 28 locations, indicating that such resistance is widely spread in the Brazilian Amazon.

Citations

Apr 1, 1984·Revista de saúde pública·O Genaro, J J Ferraroni
Nov 1, 1987·Revista Do Instituto De Medicina Tropical De São Paulo·M A SantosV E Rosário
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·J J FerraroniR Shrimpton
Apr 1, 1985·Parasitology·W Peters
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·J Le BrasB Larouze
Apr 2, 2015·Expert Review of Anti-infective Therapy·Lorenz von Seidlein, Arjen Dondorp
Oct 1, 1982·Revista de saúde pública·F H AlencarR Shrimpton
Sep 1, 1996·Revista Da Sociedade Brasileira De Medicina Tropical·H M UenoE Salata
Sep 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MaynadiéL Yarzabal

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