Prevalence of clinically important histology in small adenomas

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
L F ButterlyGale S Fiarman

Abstract

The prevalence of advanced histology in small polyps has become a crucial issue in optimizing colorectal cancer screening strategies, especially in view of the advent of computed tomography colonography. We evaluated the prevalence of advanced histology in small and diminutive adenomas to clarify their clinical importance in terms of malignant potential. Data were reviewed retrospectively from 3291 colonoscopies performed on asymptomatic patients found to have an adenoma on screening with flexible sigmoidoscopy a few weeks before the colonoscopy or who had a family history of colorectal cancer. All polyps were excised endoscopically and sent for pathology testing. Specimens with advanced histology were confirmed by a second reading. Of the 3291 colonoscopies performed, 1235 colonoscopies yielded a total of 1933 small or diminutive adenomatous polyps. Advanced histology including carcinoma was found in 10.1% of small (5-10 mm) adenomas and in 1.7% of diminutive adenomas (< or = 4 mm). Carcinoma was found in .9% of small adenomas, and 0% of diminutive adenomas. Of the 107 patients found to have polyps 2-10 mm with advanced histology, 100 (93%) were referred for colonoscopy because of an adenoma found on a recent screening with fl...Continue Reading

References

Dec 1, 1979·Annals of Surgery·H Shinya, W I Wolff
Dec 1, 1975·Cancer·T MutoB C Morson
Mar 5, 1992·The New England Journal of Medicine·W S AtkinJ Cuzick
Jan 1, 1988·Diseases of the Colon and Rectum·S J UrbanskiN E Marcon
Sep 1, 1985·Endoscopy·W MatekL Demling
Feb 1, 1982·Gastrointestinal Endoscopy·F J TedescoL R Mills
Dec 30, 1993·The New England Journal of Medicine·S J WinawerJ F Panish
Feb 1, 1993·The Australian and New Zealand Journal of Surgery·P H ChapuisR C Newland
Apr 1, 1996·Seminars in Roentgenology·D J Ott
Jan 2, 1997·The New England Journal of Medicine·T E ReadL F Butterly
Mar 1, 1997·Gastroenterology Clinics of North America·A G Zauber, S J Winawer
Nov 24, 1999·The New England Journal of Medicine·H M FenlonJ T Ferrucci
Dec 6, 2003·The New England Journal of Medicine·Perry J PickhardtWilliam R Schindler
Dec 23, 2003·Expert Review of Anticancer Therapy·Angel Ferrández, James A DiSario
Aug 16, 1952·Journal of the American Medical Association·M WEINGARTEN, R TURELL
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Robert A SmithUNKNOWN American Cancer Society
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Peter B CottonHarold Butler
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Uri LadabaumA Mark Fendrick
Oct 12, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael J O'brienUNKNOWN National Polyp Study Workgroup
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani

❮ Previous
Next ❯

Citations

Sep 25, 2008·JAMA : the Journal of the American Medical Association·David A LiebermanCynthia D Morris
Sep 25, 2008·JAMA : the Journal of the American Medical Association·Hemant K Roy, Laura K Bianchi
Dec 26, 2008·Abdominal Imaging·Franco IafrateAndrea Laghi
Jun 28, 2008·European Radiology·Ifigeneia MavranezouliStuart A Taylor
Sep 28, 2012·International Journal of Colorectal Disease·Flavia PigòRita Luisa Conigliaro
Sep 16, 2011·Digestive Diseases and Sciences·Brent LeeDavid Lieberman
Jan 13, 2012·Journal of General Internal Medicine·Tuan A DinhRobert Smith
Sep 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Robert E Schoen, Chin Hur
Jan 4, 2008·The New England Journal of Medicine·Douglas K Rex, Thomas F Imperiale
Sep 18, 2009·The New England Journal of Medicine·David A Lieberman
Oct 5, 2007·The New England Journal of Medicine·David H KimPatrick R Pfau
Sep 19, 2008·The New England Journal of Medicine·C Daniel JohnsonPaul J Limburg
Aug 7, 2010·Southern Medical Journal·Mitchell S Cappell, Mihaela Batke
Dec 10, 2009·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jay P Heiken
Jun 28, 2011·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Jean-Francois ReyShinji Tanaka
Jun 8, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C A RubioJ G Jonasson
Jan 14, 2009·Cancer Prevention Research·Elena M StoffelUNKNOWN Great Lakes New England Clinical Epidemiology and Validation Center of the Early Detection Research Network
Jan 14, 2009·Cancer Prevention Research·Elena M StoffelUNKNOWN Great Lakes-New England Clinical Epidemiology and Validation Center of the Early Detection Research Network
Dec 21, 2007·AJR. American Journal of Roentgenology·Perry J PickhardtSergio Morini
Jul 31, 2008·World Journal of Gastroenterology : WJG·Mitsuhiro Fujishiro
Apr 20, 2014·World Journal of Gastroenterology : WJG·Kiyoshi OkaJunji Yoshino
Feb 15, 2011·Digestive Diseases and Sciences·Franklin C Tsai, Williamson B Strum
Oct 16, 2012·Digestive Diseases and Sciences·Ashish ShuklaSushovan Guha
Apr 14, 2015·Scandinavian Journal of Gastroenterology·Marek BugajskiJaroslaw Regula
Apr 25, 2007·Cancer Investigation·Nikhil Deshpande, David S Weinberg
Aug 13, 2013·Gastroenterology Clinics of North America·Zilla H Hussain, Heiko Pohl
Mar 25, 2016·The Indian Journal of Surgery·Ali AktekinGul Babacan Abanonu
Apr 2, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tuan DinhTheodore R Levin
Feb 5, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Pier Alberto TestoniEdi Viale
Mar 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Swati G PatelSachin Wani
Oct 2, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Meital BlochAbraham Rubinstein
Jul 20, 2012·Medicina clínica·Matilde NavarroIgnacio Blanco

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