Prevalence of Comorbidity in Patients With Young-Onset Alzheimer Disease Compared With Late-Onset: A Comparative Cohort Study

Journal of the American Medical Directors Association
Adrie A J Gerritsen4C study team

Abstract

With the lack of a cure for Alzheimer disease (AD), the identification of comorbidity is important to reduce the possibility of excess disability. Although comorbidity in patients with late-onset AD (LO-AD) is common, for people with young-onset AD (YO-AD), it is unclear how often comorbidity occurs. Furthermore, it is uncertain whether comorbidity in patients with YO-AD differs from that in patients with LO-AD. The aim of this study was to explore the prevalence, types of morbidity, and morbidity profiles in patients with YO-AD compared with those of patients with LO-AD. Explorative cohort study from 2 separate Dutch cohorts (Needs in Young-onset Dementia [NeedYD] and the Clinical Course of Cognition and Comorbidity-Dementia Study [4C-Dementia study]). Participants were recruited in 2007 and 2008 from (1) the memory clinics of 3 Dutch Alzheimer centers, (2) the memory clinics of general hospitals, (3) mental health services in the southern part of the Netherlands, and (4) young-onset dementia specialized day care facilities. A comparison group of community-dwelling, elderly patients with AD was selected from the 4C-Dementia study. Patients in this study were recruited in 2010 and 2011 from the aforementioned Alzheimer centers....Continue Reading

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Citations

Aug 15, 2017·Journal of Neurochemistry·Janou A Y RoubroeksKatie Lunnon
Nov 25, 2017·Journal of Alzheimer's Disease : JAD·Linda LimNagaendran Kandiah
Feb 2, 2019·Continuum : Lifelong Learning in Neurology·Mario F Mendez
Oct 26, 2018·Journal of Internal Medicine·A Calderón-LarrañagaL Fratiglioni
Jan 30, 2018·Journal of Alzheimer's Disease : JAD·Mathilde FrançoisNathalie Pelletier Fleury
Mar 12, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jennifer L WhitwellKeith A Josephs
Jul 4, 2019·Journal of Molecular Neuroscience : MN·Polyxeni StamatiEfthimios Dardiotis
Jul 31, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Janet L MacNeil-VroomenHeather G Allore
Mar 28, 2019·International Psychogeriatrics·Adrie A J GerritsenRaymond T C M Koopmans
Dec 22, 2020·Neurochemistry International·Vaibhav WaliaNeeraj Kumar Sethiya
Jul 20, 2020·Ageing Research Reviews·Amalia C BruniCarlo Gabelli
Sep 9, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Adam MartersteckEmily Rogalski

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