Prevalence of conditions causing chronic anovulation and the proposed algorithm for anovulation evaluation

The Journal of Obstetrics and Gynaecology Research
Pitch Chandeying, Tawiwan Pantasri

Abstract

This study investigated the prevalence of disease-causing chronic anovulation and proposes a logical investigation flowchart to facilitate diagnosis in women presenting with chronic anovulation. The cross-sectional retrospective study was performed using 293 reproductive-aged women who were diagnosed with chronic anovulation at the Gynecologic Endocrinology Unit, Faculty of Medicine, Chiang Mai University between January 2008 and December 2012. The demographic data, laboratory investigations and diagnoses were collected. Among 293 patients recruited into the study, the common causes of anovulation were polycystic ovary syndrome (PCOS) (73.4%), prolactin disorder (13.3%) and unexplained chronic anovulation (7.5%). The less common causes were thyroid disorders, congenital adrenal hyperplasia, adrenal tumors and Cushing's disease. There was a strong positive association between the levels of 17-hydroxyprogesterone and/or dehydroepiandrosterone sulfate with the levels of testosterone and androstenedione. The sensitivity and specificity of serum luteinizing hormone to accurately diagnose PCOS were 29.38% and 55.56% (P = 0.03). The luteinizing hormone/follicle-stimulating hormone ratio ≥ 3 had a sensitivity and specificity at 18.56% ...Continue Reading

References

Feb 1, 1985·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L BahamondesJ A Pinotti
Apr 16, 1988·Lancet·D W PolsonS Franks
Jan 1, 1985·Annals of the New York Academy of Sciences·S PangM I New
Jan 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P YlöstaloK Kontula
Sep 1, 1982·The Journal of Clinical Endocrinology and Metabolism·S PangM I New
Jan 1, 1995·The Journal of Pediatrics·W S Cutfield, D Webster
Apr 30, 2002·Metabolism: Clinical and Experimental·John E MorleyH M Perry
Sep 6, 2003·BMJ : British Medical Journal·Diana Hamilton-Fairley, Alison Taylor
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
May 18, 2006·Annals of Clinical Biochemistry·Li Wei ChoStephen L Atkin
Jul 11, 2006·Clinics in Dermatology·Paulina A EssahJohn E Nestler
Jun 14, 2008·Reproductive Biomedicine Online·M L HendriksC B Lambalk
Oct 11, 2008·Dermatologic Therapy·Najwa SomaniWilma F Bergfeld
Oct 28, 2008·Fertility and Sterility·Ricardo AzzizUNKNOWN Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Jul 19, 2011·Fertility and Sterility·Xiaomiao ZhaoDongzi Yang
Jun 19, 2012·Best Practice & Research. Clinical Obstetrics & Gynaecology·Raymond Hang Wun Li, Ernest Hung Yu Ng
Aug 29, 2013·Clinical Epidemiology·Kristen A HahnElizabeth E Hatch

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Citations

Mar 2, 2016·Hormones & Cancer·Tess V ClendenenAnne Zeleniuch-Jacquotte
Feb 1, 2018·Human Fertility : Journal of the British Fertility Society·Hande Çekici, Yasemin Akdevelioğlu
Jul 22, 2020·Obstetrics & Gynecology Science·Gyung-Mee Kim, Gyun-Ho Jeon
Sep 12, 2018·Journal of Menopausal Medicine·Siripen OngsupharnNuntana Morakote
Oct 22, 2020·Sleep & Breathing = Schlaf & Atmung·Paula AraujoMonica Levy Andersen

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