PMID: 9427895Jan 15, 1998Paper

Prevalence of coronary artery abnormalities in Kawasaki disease is highly dependent on gamma globulin dose but independent of salicylate dose

The Journal of Pediatrics
M Terai, Stanford T Shulman

Abstract

The efficacy of intravenous gamma globulin (IVGG) for treatment of Kawasaki disease (KD) is clearly established. In a metaanalysis, we reviewed U.S. and Japanese multicenter, randomized controlled studies regarding the effect of various doses of IVGG with aspirin administered within the first 7 to 10 days of illness on the prevalence of coronary artery abnormalities in KD. We studied 1629 patients with acute KD from the six reported studies that included blinded echocardiographic assessments. In 868 Japanese patients treated with moderate-dose aspirin (30 to 50 mg/kg per day), the prevalence of coronary abnormalities at the subacute stage (illness day 30) was 26.8% with aspirin alone, 18.1% with total IVGG dose < 1 gm/kg, 17.3% with total IVGG of 1.0 to 1.2 g/kg, and 5.3% with total IVGG of 2 gm/kg; the corresponding prevalence at the convalescent stage of illness (illness day 60) was 17.5%, 13.5%, 9.8%, and 3.5%, respectively. In 761 U.S. patients treated with high-dose aspirin (80 to 120 mg/kg per day), the prevalence of coronary abnormalities at the subacute stage (2 to 3 weeks after enrollment) was 23.0% with aspirin alone, 9.0% with total IVGG of 1.0 gm/kg, 8.6% with total IVGG of 1.6 gm/kg, and 4.6% with total IVGG of 2.0...Continue Reading

References

Dec 1, 1991·Acta Paediatrica Japonica; Overseas Edition·K Harada
Aug 7, 1986·The New England Journal of Medicine·J W NewburgerS P Sanders
May 1, 1987·The Journal of Pediatrics·M NagashimaN Okumura
Nov 1, 1989·American Journal of Diseases of Children·M A EngleM L Lesser
Nov 10, 1984·Lancet·K FurushoT Yokoyama
May 1, 1993·Circulation·A S DajaniW Wilson

❮ Previous
Next ❯

Citations

Mar 7, 2003·Indian Journal of Pediatrics·Monesha L GuptaP Syamasundar Rao
Mar 10, 2010·Pediatric Cardiology·Jennifer S Li, Jane W Newburger
Oct 4, 2011·Pediatric Cardiology·Xiaomei ZhangJinghui Sun
Nov 23, 2011·Pediatric Cardiology·Jae-Jung KimUNKNOWN Korean Kawasaki Disease Genetics Consortium
Dec 6, 2011·Zeitschrift für Rheumatologie·U Neudorf
Sep 26, 2006·Journal of Neurology·Andreas Steinbrecher, Peter Berlit
Jul 3, 2002·Current Treatment Options in Cardiovascular Medicine·Erik C. Michelfelder, David Shim
May 9, 2007·Current Treatment Options in Cardiovascular Medicine·Jane W Newburger, David R Fulton
Mar 11, 2004·Experimental and Molecular Pathology·Monesha Gupta-MalhotraJohn B Zabriskie
Oct 13, 1999·The Journal of Pediatrics·M ShinoharaA Morikawa
Apr 28, 1999·Pediatric Clinics of North America·A H Rowley, S T Shulman
Sep 11, 2003·Autoimmunity Reviews·Rolando Cimaz, Fernanda Falcini
Jul 27, 2011·Cardiology in the Young·Gi-Beom KimJung-Yun Choi
Feb 7, 2001·Eye·G G KamathL G Clearkin
Feb 16, 2007·The New England Journal of Medicine·Jane W NewburgerUNKNOWN Pediatric Heart Network Investigators
Apr 23, 2003·Current Opinion in Rheumatology·Yolanda Braun-Moscovici, Daniel E Furst
Apr 25, 2006·Journal of Paediatrics and Child Health·Paul HeatonGeoff Aiken
Aug 11, 2006·Journal of Paediatrics and Child Health·Kyung-Yil LeeDavid Burgner
Oct 29, 2013·Archives of Disease in Childhood·D EleftheriouP A Brogan
Jul 22, 2011·Pediatric Rheumatology Online Journal·Fernanda FalciniDonato Rigante
Jun 22, 2011·Journal of Epidemiology·Dambadarjaa DavaalkhamTomisaku Kawasaki
Feb 19, 2009·Annals of Tropical Paediatrics·I Shah, S S Prabhu
Aug 9, 2013·Rheumatology International·Raghvendra Singh MeenaSurjit Singh
Nov 13, 2002·Current Rheumatology Reports·Robert P Sundel
Dec 3, 2011·European Journal of Pediatrics·Cedric ManlhiotRae S M Yeung
Sep 17, 2013·Journal of the American Academy of Dermatology·Stephanie BayersAmy S Paller
May 9, 2012·Pediatric Clinics of North America·Rosie Scuccimarri
May 24, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·V BressonE Bosdure
Jun 11, 2009·Best Practice & Research. Clinical Rheumatology·Despina Eleftheriou, Paul A Brogan
Nov 29, 2008·The Journal of Pediatrics·Annette L BakerUNKNOWN Pediatric Heart Network Investigators
Jun 7, 2008·The Journal of Pediatrics·Negar AshouriWilbert Mason
Feb 19, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Daisuke HazekiYoshifumi Kawano
Jun 16, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Cedric ManlhiotBrian W McCrindle
May 20, 2006·Thrombosis Research·Sara J Israels, Alan D Michelson
Apr 16, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·UNKNOWN Research Committee of the Japanese Society of Pediatric Cardiology, UNKNOWN Cardiac Surgery Committee for Development of Guidelines for Medical Treatment of Acute Kawasaki Disease
Apr 25, 2015·Nature Reviews. Rheumatology·Stanford T Shulman, Anne H Rowley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.