PMID: 19123309Jan 7, 2009Paper

Prevalence of Coxiella burnetii antibodies in blood donors in Ankara, Central Anatolia, Turkey

The New Microbiologica
S KiliçEsra Alp Karakoc

Abstract

The aims of this study were to determine the prevalence of Coxiella burnetii antibodies among blood donors and to examine the epidemiological characteristics of C. bumetii infection in Ankara, Turkey. A total of 601 serum samples were collected from blood donors aged 18-61 years. Donor samples were stratified by age, sex, and residence (rural or urban). IgG and IgM antibodies to the C. bumetii phase II antigen were determined using a commercial ELISA. Blood samples reactive in the ELISA were also analysed using a commercial indirect immunofluorescence assay (IFA). The prevalence of anti-phase II IgG was 32.3%, and 17 (2.8%) were IgM positive. Seropositivity in men was higher than in women (33.2% vs. 21.7%, OR:1.88; 95% CI: 0.88-4.14) and the difference in seroprevalence rates between genders was not related to occupational exposure to domestic animals. 87.6% of seropositive donors reported no contact with farm animals. Our results revealed that C. burnetii infection is highly endemic in Ankara and that the majority of seropositive cases are not linked to specific occupational exposure in this area. In conclusion, the high rate of C. burnetii phase II antibodies among blood donors is a reflection of the high prevalence of Q feve...Continue Reading

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