Prevalence of diabetes and incidence of angiopathy in patients with chronic viral liver disease

Journal of Clinical Biochemistry and Nutrition
Shoko KuriyamaHisataka Moriwaki

Abstract

Patients with chronic liver disease (CLD) often develops glucose intolerance. We explored the prevalence of diabetes mellitus in viral CLD, and analyzed factors profoundly affecting the diabetic angiopathies. 229 CLD patients (124 chronic hepatitis and 105 liver cirrhosis) entered the study. The diagnosis of diabetes was made with the criteria by World Health Organization. Laboratory investigation included serum asparate aminotransferase, alanine aminotransferase, albumin, fasting blood sugar, hemoglobin A1c (HbA1c), fasting immunoreactive insulin, and HOMA-R (FBS*IRI/405). The incidence of macro- and microangiopathy were also examined. Forty (17.5%) CLD patients were diagnosed diabetes, giving a significantly higher incidence than that of general cohort (5.3%) (p<0.001). Among them, 12 (30%) had the triopathy, significantly lower than that in a matched group of diabetic patients without CLD (65%) (p<0.001). Significantly increased levels of HbA1c and HOMA-R were observed in diabetic CLD with angiopathy compared with diabetic CLD without. Incidence of diabetes was increased in viral CLD patients. The rate of diabetic angiopathies in CLD, however, was relatively low, this could be explained by low coagulability in these patients...Continue Reading

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Citations

Jul 28, 2011·Virology Journal·Eman I ElhawaryMohamed Abdel-Hamid
May 16, 2009·Internal Medicine·Hirohito ShimizuShogo Iwabuchi
Jul 7, 2011·World Journal of Hepatology·Takumi KawaguchiMichio Sata
Nov 29, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ester VanniGiorgio Saracco
Mar 4, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Claudia CoppoGiorgio Maria Saracco
Mar 15, 2015·Transplantation Proceedings·M-S TongC-L Hang
Mar 23, 2019·Diabetes/metabolism Research and Reviews·Wai Gin LeeLindsay D Plank
Nov 9, 2017·Oncotarget·Ping-Hsin HsiehYung-Po Liaw
Oct 19, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Yi ShenFeng Liang

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