Prevalence of drug-drug interactions with pangenotypic direct-acting antivirals for hepatitis C and real-world care management in the United States: a retrospective observational study.

Journal of Managed Care & Specialty Pharmacy
Michael P CurryNezam Afdhal

Abstract

BACKGROUND: Direct-acting antiviral (DAA) regimens for hepatitis C virus (HCV) have varying potentials for drug-drug interactions (DDIs). OBJECTIVES: To (1) identify prevalence of potential DDI with glecaprevir-pibrentasvir (GLE-PIB) and sofosbuvir-velpatasvir (SOF-VEL) and (2) describe health care provider actions in response to pharmacist recommendations based on potential interactions with GLE-PIB or SOF-VEL, using 2 complementary data sources. METHODS: Possible interacting drugs were identified among adult patients in a United States electronic medical record database covering 21 health care organizations and 26 million patients in 2018. DDIs were categorized as potential weak interaction (Level 1), potential interaction (Level 2), or contraindicated (Level 3). Real-world recommendations and resultant actions regarding DDIs with GLE-PIB and SOF-VEL were obtained from a specialty pharmacy database. Categorical variable comparisons were done via chi-square analysis with subsequent z-tests of column proportions. RESULTS: DDI prevalence was higher for patients prescribed GLE-PIB (317/769 [41%]) compared with those prescribed SOF-VEL (170/633 [27%]), and the prevalence of a Level 3 (contraindicated) interaction was higher with G...Continue Reading

References

May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Dec 3, 2014·Journal of Hepatology·Rachel H Westbrook, Geoffrey Dusheiko
Jul 24, 2015·MMWR. Morbidity and Mortality Weekly Report·Kiren MitrukaFrancisco Averhoff
Mar 16, 2017·BMC Medicine·Thomas F BaumertYujin Hoshida
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Aug 23, 2019·Journal of Hepatology·Elisabetta DegasperiUNKNOWN NAVIGATORE-Lombardia and Veneto Study Groups
May 26, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandra MangiaJuan Turnes
Oct 22, 2020·Journal of Clinical and Translational Hepatology·Jenny HongTrana Hussaini

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