Prevalence of drug-induced electrocardiographic pattern of the Brugada syndrome in a healthy population

The American Journal of Cardiology
Jean-Sylvain HermidaJean-Luc Rey

Abstract

To determine the prevalence of drug-induced Brugada's syndrome (BrS) electrocardiograms (ECGs) in a healthy population, a sodium channel blockade challenge was performed in previously identified subjects with BrS-compatible (BrC) ECGs. These subjects were detected in 1,000 normal patients in whom first ECGs were systematically recorded. Because of the intermittent nature of electrocardiographic modifications in BrS, second ECGs were also recorded in a representative sample of the population presenting with first ECGs with normal results. The prevalence of typical drug-induced BrS ECGs was 5 of the 1,000 patients. This value was fivefold greater than the reported prevalence of spontaneous BrS ECGs in the healthy population.

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Citations

Jun 2, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yee Guan YapA John Camm
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Dec 17, 2017·Clinical Cardiology·Nikhil Mehta, Robert Vannozzi
Jan 17, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jean-Sylvain HermidaGeneviève Jarry
Jan 14, 2020·Circulation·Xiayan ShenDaniel T T Chong
Aug 28, 2020·Curēus·Venkatesh RaviParikshit S Sharma

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