Prevalence of drug resistance in children recently diagnosed with HIV-1 infection in France (2006-17): impact on susceptibility to first-line strategies

The Journal of Antimicrobial Chemotherapy
Pierre FrangeMarie-Laure Chaix

Abstract

To describe the prevalence of transmitted drug resistance (TDR) among 84 children newly diagnosed with HIV in France in 2006-17. HIV-1 resistance-associated mutations (RAMs) were characterized using both the 2009 Stanford list of mutations and the 2017 French National Agency for AIDS Research (ANRS) algorithm. A genotypic susceptibility score (GSS) was estimated for each first-line recommended ART combination. Patients were mainly infected through mother-to-child transmission (MTCT) (73/84; 86.9%), but only 18 children (24.7% of vertically infected patients) were previously exposed to antiretroviral prophylaxis from MTCT. Non-B variants were identified in 90.5% (76/84) of patients. The frequency of TDR was 8.3% (7/84) using the 2009 Stanford list and 16.7% (14/84) using both the Stanford list and the 2017 ANRS algorithm. The prevalence of PI-, NRTI-, efavirenz/nevirapine-, etravirine/rilpivirine- and doravirine-associated RAMs was 0%, 3.6%, 6.0%, 11.9% and 2.4%, respectively. Single-, dual- and triple-class resistance was present in 15.5%, 1.2% and 0% of cases, respectively. Additionally, 3/60 (5%) strains had integrase inhibitor (INI)-related RAMs (an isolated E157Q mutation, which could mostly affect the susceptibility to ral...Continue Reading

References

Oct 11, 2013·The Pediatric Infectious Disease Journal·Pierre FrangeStéphane Blanche
Jul 23, 2015·AIDS Research and Human Retroviruses·Sara Nunes VazCarlos Brites
Jan 22, 2017·Asian Pacific Journal of Tropical Medicine·Rozainanee Mohd ZainRavindran Thayan
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Solange Dourado de AndradeAmilcar Tanuri
Oct 11, 2017·The Pediatric Infectious Disease Journal·Patricia Rojas SánchezUNKNOWN Madrid Cohort of HIV-1 Infected Children and Adolescents Integrated in the Pediatric Branch of the Spanish National AIDS Net
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael R JordanSilvia Bertagnolio
Jan 19, 2018·Viruses·Charlotte Charpentier, Diane Descamps

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