Prevalence of elevated hemoglobin A2 measured by the CAPILLARYS system

American Journal of Clinical Pathology
Zhaohai YangVishnu V B Reddy

Abstract

Hemoglobin (Hb) A2 electrophoresis has been used for prenatal screening for the beta-thalassemia trait (betaTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA2 in the HbAA-pregnancy group had betaTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA2 in the HbAA-other group, 5 had betaTT and 2 were normal. The number of patients without betaTT but with HbA2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA2 cutoff (3.5%) was used, only 3 pregnant patients without betaTT had HbA2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA2 elevation had no evidence of betaTT, compared with the nonpregnant group.

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Citations

Mar 21, 2012·American Journal of Clinical Pathology·David F KerenDeborah Hedstrom
Aug 23, 2012·American Journal of Clinical Pathology·Eloísa Urrechaga
Jul 14, 2009·Clinical Biochemistry·Antonino GiambonaAurelio Maggio
May 27, 2014·Blood Cells, Molecules & Diseases·Ji-Wu LouYan-Hui Liu
Oct 22, 2011·The Korean journal of laboratory medicine·Ji-Eun KimJin-Yeong Han
Jul 9, 2014·The Kaohsiung Journal of Medical Sciences·Chung-King LinYung-Chuan Sung
Mar 16, 2011·The Tohoku Journal of Experimental Medicine·Zhanhui OuXiaofang Sun
Jul 12, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Meric A Altinoz, Bahri Ince

Related Concepts

Hemoglobin A2
Pregnancy Complications, Hematologic
Antenatal Screening Procedures
Retrospective Studies
Thalassemia Minor
Electrophoresis, Capillary
Electrophoresis
Erythrocytes
Hemoglobin A2
Hemoglobinopathies

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