Prevalence of Enhancer of Zeste Homolog 2 in Patients with Resected Small Cell Lung Cancer

Anticancer Research
Gouji ToyokawaYoshihiko Maehara

Abstract

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is deeply involved in cancer pathogenesis. Although clinicopathological significance of EZH2 in non-small cell lung cancer has been gradually elucidated, such significance in small cell lung cancer (SCLC) has yet to be fully investigated. Forty patients with resected SCLC were analyzed for EZH2. EZH2 expression was evaluated using the Allred score (0-8) and was classified into negative (0-6) and positive (7 and 8). We evaluated the association between EZH2 and the clinicopathological characteristics and postoperative survivals. Among 40 patients, 15 (37.5%) and 25 (62.5%) were classified as being negative and positive for EZH2, respectively. Fisher's exact test demonstrated no significant associations between the positivity for EZH2 and clinicopathological characteristics. No significant differences were observed in recurrence-free and overall survivals between EZH2-negative/low and EZH2-high patients. EZH2 was frequently observed in patients with resected SCLC, but no significant associations were found between its expression and the clinicopathological characteristics and postoperative survivals.

Citations

May 22, 2019·Cancers·Arik Bernard SchulzeLars Henning Schmidt
Jun 16, 2019·Virchows Archiv : an International Journal of Pathology·Serdar AltinayMauro Papotti
Dec 20, 2020·International Journal of Molecular Sciences·Francesco Paolo FiorentinoLuigi Bagella
Nov 18, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yeon Bi HanJin-Haeng Chung

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