Abstract
Extended spectrum β-lactamase (ESBL) are gram-negative bacteria that produce the enzyme, β-lactamase, which can break down commonly used antibiotics, such as penicillin and cephalosporins, making infections with ESBL producing bacteria more difficult to treat. Extended spectrum β-lactamase-producing Klebsiella pneumoniae were first reported in 1983 from Germany, and since then a steady increase in resistance against cephalosporins has been seen causing health problems. The aim of this study was to determine the prevalence of ESBL in strains of K. pneumoniae isolated from different clinical samples. One hundred and thirty isolates of K. pneumoniae were isolated from different clinical specimens from King Khalid hospital, Hafr Elbatin, Kingdom Saudi Arabia. These isolates were then characterized, tested for antimicrobial susceptibility and screened for ESBL production by the MicroScan WalkAway-96 SI System. Extended spectrum β-lactamase production was confirmed by the phenotypic confirmatory disc diffusion test (PCDDT) and the double disc synergy test (DDST). Overall, 76.9% (100) of the isolates were resistant to cefuroxime, cefepime and cefazolin, 69.23% (90) were resistant to cefotaxime, and 46.15% (60) were resistant to cefoxi...Continue Reading
References
Sep 1, 1989·Infection·A BauernfeindS Schweighart
May 1, 1971·Annals of Internal Medicine·R SeldenT C Eickhoff
Aug 1, 1997·Journal of Clinical Microbiology·C L Emery, L A Weymouth
Sep 17, 1998·Journal of Clinical Microbiology·K ShannonG French
Dec 10, 1999·The Journal of Antimicrobial Chemotherapy·A PałuchaM Gniadkowski
Jun 6, 2000·The Journal of Antimicrobial Chemotherapy·G SaurinaD Landman
May 29, 2001·Journal of Clinical Microbiology·D L PatersonV L Yu
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Louis B. Rice, Robert A. Bonomo
Oct 5, 2001·Clinical Microbiology Reviews·P A Bradford
Jan 5, 2002·Diagnostic Microbiology and Infectious Disease·H Goossens, UNKNOWN MYSTIC Study Group (Europe)
Nov 19, 2002·Antimicrobial Agents and Chemotherapy·Ellen Smith MolandKenneth S Thomson
Nov 26, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F M MacKenzieI M Gould
Oct 15, 2003·The Journal of Infection·Enno Stürenburg, Dietrich Mack
Jun 2, 2005·Indian Journal of Medical Microbiology·S Ananthan, A Subha
Oct 5, 2007·Diagnostic Microbiology and Infectious Disease·Emilio David Valverde RomeroJuan Luis Muñoz Bellido
Dec 19, 2007·Indian Journal of Medical Microbiology·S HoşoğluH Ucmak
Jul 1, 2008·Pathologie-biologie·Y MessaiR Bakour