Prevalence of extended spectrum beta-lactamases among Enterobacteriaceae: an Italian survey

International Journal of Antimicrobial Agents
G BonfiglioGiuseppe Nicoletti

Abstract

The prevalence of extended-spectrum beta-lactamase (ESBL) production by consecutive non-repeated isolates of Enterobacteriaceae was determined over a 6-month period. A total of 8015 strains were isolated from ten Italian laboratories and 509 (6.3%) of these were designated ESBL producers from the results of a double-disk synergy test. Escherichia coli was the most isolated microrganism, followed by Klebsiella pneumoniae and Proteus mirabilis. Providencia stuartii (28.1%) was the most frequently isolated ESBL producer, followed by K. pneumoniae and Enterobacter aerogenes (20.5%). However, amongst all ESBL producers, K. pneumoniae (38.2%) was the most represented followed by P. mirabilis (25.7%). All the strains positive to DD tests were confirmed for the carriage of TEM and SHV genes using colony-blot hybridisation (CH). A total of 447 strains (88.0%) were CH-positive, of which 42.3% hybridised with the TEM-type probe, 30.1% with the SHV-type probe and 15.6% with both probes. In conclusion, our findings indicate that 6.3% of all Enterobacteriaceae tested produced ESBLs, 42.3% of which were TEM-derived enzymes. More than 20% of P. stuartii, K. pneumoniae and E. aerogenes harbour these enzymes. The double-disk test seems to be a u...Continue Reading

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Citations

Apr 15, 2004·Indian Journal of Pediatrics·Jocelyn Y AngBasim I Asmar
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Jacob SchlesingerYehuda Carmeli
Mar 16, 2005·Chemotherapy·Agata LanzafameRoberto Mattina
Apr 5, 2005·Indian Journal of Medical Sciences·Rashmi SharmaBhuvneshwar Kapoor
Aug 31, 2004·Journal of Chemotherapy·G BaharZ Gülay
Jul 16, 2003·Current Opinion in Infectious Diseases·Rafael CantónFernando Baquero

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