Prevalence of factor V Leiden and prothrombin G20210A mutations in Chinese patients with deep venous thrombosis and pulmonary embolism

Clinical and Laboratory Haematology
Z J JunW Jing

Abstract

Venous thromboembolism (VTE) is a common vascular disease that results in two major clinical manifestations: deep venous thrombosis (DVT) and pulmonary embolism (PE). Several genetic risk factors, especially factor V Leiden and prothrombin G20210A mutations have been reported to be related to VTE in Caucasians, but the relationship remains controversial in other populations. Thus, the objective of the present study was to compare the frequency of the two mutations and also to investigate whether acquired risk factors other than genetic mutations may play a different role in Chinese VTE patients. Thirty-five patients were diagnosed with DVT concomitant PE, 178 patients with DVT, 54 patients with PE and 102 control subjects were recruited. The mutation was determined by the polymerase chain reaction-restriction fragment length polymorphism method. Of all subjects, none was a carrier of factor V Leiden or prothrombin G20210A mutations. The frequency of surgery was significantly higher in the PE group than that in other groups. There was no significant difference among the three groups in other known risk factors. The data presented here indicate that factor V Leiden and prothrombin G20210A mutations are very rare in the Chinese po...Continue Reading

References

Oct 28, 1995·Lancet·D C ReesJ B Clegg
Aug 1, 1997·British Journal of Haematology·A M CummingC R Hay
Jul 21, 1998·Annals of Internal Medicine·M MargaglioneG Di Minno
Apr 20, 2001·The New England Journal of Medicine·U Seligsohn, A Lubetsky

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Citations

Jun 19, 2009·Journal of Thrombosis and Thrombolysis·Martina MontagnanaGiuseppe Lippi
Mar 25, 2011·Journal of Thrombosis and Thrombolysis·Lobna MaalejJalel Gargouri
Apr 17, 2007·Seminars in Hematology·Mary Cushman
Apr 17, 2008·The Journal of Obstetrics and Gynaecology Research·Siti Z OmarSunil Bhalla
Feb 11, 2010·The Journal of Obstetrics and Gynaecology Research·Thiruchelvam AyaduraiSiti Zawiah Omar
Nov 29, 2013·Journal of Thrombosis and Haemostasis : JTH·S LiaoS Chunilal
Jun 19, 2015·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·K M D GunathilakeV H W Dissanayake
May 12, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K A L DarvallA W Bradbury
Aug 16, 2014·Thrombosis Research·Peijin ZhangZhaojun Lu
Dec 18, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Chen Xin-GuangCai Hua-Cong
Feb 21, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Moon Ju JangDoyeun Oh
Mar 20, 2008·Clinical Orthopaedics and Related Research·Jun-Dong ChangKyu Man Lee
Jun 19, 2008·Pediatric Blood & Cancer·Brian Hon-Yin ChungGodfrey Chi-Fung Chan
Sep 5, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Elisabeth MazoyerUNKNOWN FITENAT Study Group
May 19, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zohreh RahimiAbbas Parsian
Aug 6, 2008·World Journal of Gastroenterology : WJG·Amit-Kumar DuttaVikram Mathews
Jan 30, 2018·Thrombosis Journal·Kang-Ling WangChern-En Chiang
Jun 10, 2019·Journal of Thrombosis and Thrombolysis·Wei-Sheng ChungCheng-Li Lin
Apr 9, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Margaret Dziadosz, Laxmi V Baxi
Jan 15, 2008·International Journal of Hematology·Pantep AngchaisuksiriArjit Tiraganjana
Aug 2, 2017·Ci Ji Yi Xue Za Zhi = Tzu-chi Medical Journal·Li-Keng Chao, Te-Chao Fang
May 11, 2018·Intestinal research·Meng-Tzu WengShu-Chen Wei
Mar 7, 2009·The Journal of the American Academy of Orthopaedic Surgeons·Norman A JohansonWilliam C Watters
May 18, 2018·Nature Reviews. Disease Primers·Menno V HuismanFrederikus A Klok
Dec 25, 2013·Journal of Orthopaedic Surgery·K H LeungP K Chan
Feb 15, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·John J Y ZhangVincent D W Nga
Jul 3, 2021·International Journal of Molecular Sciences·Elena RezusCiprian Rezus
Jul 31, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Baoyan WangHang Xu

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