Prevalence of fetal-type smooth muscle cells in the media of microvessels from hypertensive patients

Hypertension
Massimo PuatoP Pauletto

Abstract

Significant structural and functional changes in smooth muscle cells (SMCs) of microvessels (diameter 30 to 300 microm) occur in hypertension. However, in microvessels of hypertensive patients, the differentiation pattern of SMCs underlying such changes remains undefined. To analyze the differentiation pattern of SMCs (adult, postnatal, or fetal), 49 muscle biopsies (rectus abdominis) were analyzed: 16 from children (aged 11 months to 11 years), 15 from normotensive adults (aged 55 to 74 years), 18 from hypertensive adults (aged 55 to 74 years). Transverse cryosections of specimens were studied by immunocytochemistry using monoclonal antibodies SM-E7 and NM-F6, which recognize smooth muscle myosin heavy chain (MyHC) and A(pla1)-like nonmuscle MyHC, respectively. The total number of microvessels was assessed via SM-E7 staining. The number of NM-F6 positive (fetal-type SMC) or negative (adult-type SMC) microvessels was assessed. The number of microvessels per area unit was considerably lower (P<0.0005) in normotensive adults (0.22+/-0.17) than in children (0.98+/-0.61). Even more significant reduction was found in hypertensive adults compared with control adults (P=0.013) and children (P<0.0005). The qualitative immunocytochemist...Continue Reading

References

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Feb 1, 1994·American Journal of Hypertension·D RizzoniE Agabiti-Rosei

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Citations

Aug 14, 2009·Journal of Human Hypertension·R HumarE Battegay
Feb 22, 2012·Circulation Research·Gian Paolo FadiniStefanie Dimmeler
Mar 21, 2009·Journal of Hypertension·Damiano RizzoniEnrico Agabiti Rosei
Aug 9, 2012·Journal of Hypertension·Marcello RattazziPaolo Pauletto
Sep 30, 2006·Annals of Medicine·Craig S StumpJames R Sowers
Jul 26, 2011·Science China. Life Sciences·Wei Zhang, Mohamed Trebak
Jun 15, 2006·Mayo Clinic Proceedings·Craig S StumpJames R Sowers
Oct 7, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ida PerrottaMauro Cassese
Aug 7, 2007·Journal of the Cardiometabolic Syndrome·Ravi Nistala, Craig S Stump
Feb 9, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paolo Pauletto, Marcello Rattazzi

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