Prevalence of fragrance contact allergy in the general population of five European countries: a cross-sectional study

The British Journal of Dermatology
T L DiepgenL Naldi

Abstract

Contact allergy to fragrances is assessed mostly in clinical populations of patients. Studies in the general population are scarce and vary in their methodology across countries. To determine the prevalence of fragrance contact allergy in the European general population and to assess the clinical relevance of positive patch test reactions to different fragrances. In five European countries (Germany, Italy, the Netherlands, Portugal and Sweden) a random sample from the general population aged 18-74 years was drawn. In total, 12 377 subjects were interviewed in this cross-sectional study and a random sample (n = 3119) was patch tested using the TRUE Test and Finn Chamber techniques. Patch test procedures were harmonized by mandatory training before the study and monitoring during the study. The highest prevalence for contact allergy of 2·6% [95% confidence interval (CI) 2·1-3·2] was found for fragrance mix (FM) I in petrolatum, with a high content of atranol and chloratranol, followed by 1·9% (95% CI 1·5-2·4) for FM II in petrolatum. The conservatively estimated prevalence of fragrance contact allergy was 1·9% (95% CI 1·5-2·5). This is defined as the existence of a positive patch test to FM I or FM II; any of their individual mat...Continue Reading

References

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Jan 24, 2013·Dermatitis : Contact, Atopic, Occupational, Drug·Anthony F FranswayMatthew Zirwas
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Citations

Dec 29, 2015·The British Journal of Dermatology·W Uter
Dec 17, 2017·The British Journal of Dermatology·A SvenssonT L Diepgen
Nov 16, 2018·Contact Dermatitis·Juan F SilvestreVirginia Fernández-Redondo
Mar 31, 2019·Central European Journal of Public Health·Maya Grigorievna Lyapina, Maria Stoyanova Dencheva
May 2, 2020·Contact Dermatitis·Annarita AntelmiCecilia Svedman
Dec 20, 2017·Dermatitis : Contact, Atopic, Occupational, Drug·Erin M WarshawKathryn A Zug
Jul 4, 2020·Contact Dermatitis·Ayse Boyvat, Incilay Kalay Yildizhan
Sep 17, 2016·Contact Dermatitis·Carola LidénIan R White
Apr 12, 2016·The British Journal of Dermatology·C Hamann
Apr 1, 2018·Contact Dermatitis·Lina HagvallAnn-Therese Karlberg
Aug 23, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anton C de Groot
Feb 2, 2021·Current Treatment Options in Allergy·María-Antonia Pastor-Nieto, María-Elena Gatica-Ortega
Apr 30, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·M BruzeR Ofenloch
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Hannes BitterlingFlorian C Stintzing
Mar 19, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Rafet KocaFuruzan Kokturk

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