Prevalence of G6PD deficiency and associated haematological parameters in children from Botswana

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Thato MotshogeGiacomo Maria Paganotti

Abstract

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is commonly seen in malaria endemic areas as it is known to confer a selective advantage against malaria. Recently, we reported a high proportion of asymptomatic reservoir of Plasmodium vivax in Botswana, that calls for intervention with primaquine to achieve radical cure of vivax malaria. Considering that individuals with this enzyme deficiency are at risk of haemolysis following primaquine treatment, assessment of the population for the relative frequency of G6PD deficiency is imperative. Samples from 3019 children from all the districts of Botswana were successfully genotyped for polymorphisms at positions 202 and 376 of the G6PD gene. Haematological parameters were also measured. The overall population allele frequency (based on the hemizygous male frequency) was 2.30% (95% CI, 1.77-2.83), while the overall frequency of G6PD-deficient genotypes A- (hemizygote and homozygote genotypes only) was 1.26% (95% CI, 0.86-1.66). G6PD deficiency is spread in Botswana according to the historical prevalence of malaria with a North-West to South-East decreasing gradient trend. There was no association between G6PD status and P. vivax infection. G6PD A- form was found to be associated w...Continue Reading

Citations

Feb 1, 2019·PLoS Neglected Tropical Diseases·Katherine A TwohigRosalind E Howes
May 16, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Daniel H HaiyamboIsaac K Quaye
Jul 25, 2021·The Pharmacogenomics Journal·Jorge E B da RochaUNKNOWN as members of the H3Africa Consortium

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