Prevalence of glucose-6-phosphate dehydrogenase deficiency among neonates at a tertiary care centre in Lebanon

Journal of Medical Screening
A InatiNajib Tecle

Abstract

In this study we aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in a Lebanese population and the clinical outcomes and associated adverse events encountered amongst affected patients. Newborn screening in a tertiary care centre in North Lebanon showed a prevalence of 2.1% (62 out of 3009), significantly higher in males than females, and in Muslims than Christians. Among 45 infants followed for a median of 2.2 years from birth, 12 (27%) were admitted to hospital for severe haemolytic crises, despite a programme of early family education and close follow-up. A nationwide newborn screening program to identify afflicted individuals, and to augment vigilance about this disease, should be considered in countries where the disorder is prevalent.

References

Jun 18, 2002·Blood Cells, Molecules & Diseases·Ernest Beutler, Tom J Vulliamy
Jul 12, 2007·Redox Report : Communications in Free Radical Research·Hung-yao HoDaniel Tsun-yee Chiu

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Citations

Jun 5, 2014·Pharmacogenomics·Zeinab Awada, Nathalie Khoueiry Zgheib
Feb 24, 2009·Blood Cells, Molecules & Diseases·Ella T NkhomaErnest Beutler

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