Prevalence of granulomatous lesions in minor salivary gland biopsy in a case series of 65 patients with tuberculosis

La Revue de médecine interne
V DelceyJ-F Bergmann

Abstract

The distinction between tuberculosis (TB), a worldwide infectious granulomatosis requiring specific antibiotic therapy, and sarcoidosis, a rare granulomatous disease that may require corticosteroids is not straightforward and may result in diagnostic and therapeutic delay. We prospectively and consecutively evaluated the presence of epithelioid granulomas in minor salivary gland biopsy of 65 consecutive patients with TB. In our study, 10.8 % of our TB patients had epithelioid granulomas without caseous necrosis identified in their minor salivary gland biopsy, regardless of the location of TB, HIV status and whether or not the sputum examination was positive for tuberculous bacilli. The presence of epithelioid granulomas in minor salivary gland biopsy may not be helpful to the clinician to rule out TB in a patient with suspected sarcoidosis.

References

Oct 25, 1979·The New England Journal of Medicine·V J Nessan, J R Jacoway
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J D Molina-GamboaG M Ruiz-Palacios
Feb 1, 1997·American Journal of Epidemiology·B A RybickiM C Iannuzzi
Oct 5, 2013·Lancet·Dominique ValeyreJoachim Müller-Quernheim
Mar 29, 2014·Annals of Medical and Health Sciences Research·A GuptaH Singh

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Citations

Aug 27, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nadia Ben LaghaLouis Maman

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