Prevalence of hepatitis C in Swedish diabetics is low and comparable to that in health care workers

European Journal of Gastroenterology & Hepatology
Klas SjöbergHans Verbaan

Abstract

An association between hepatitis C virus (HCV) infection and diabetes has been reported, in particular from countries with a high prevalence of HCV. To assess if this association could be found in a region with low prevalence of HCV (0.33%), we determined the prevalence of anti-HCV in a large cohort of patients with diabetes. The prevalence of anti-HCV was determined with an enzyme-linked immunosorbent assay in 874 patients with diabetes representing 72.5% of a total research cohort of 1205 patients who were invited to participate. The results were confirmed with immunoblot. Samples from confirmed patients were tested for HCV RNA and genotyped. In 499 patients with type 1 diabetes and 375 patients with type 2 diabetes six patients were anti-HCV positive (four with type 1 diabetes and two with type 2 diabetes corresponding to a prevalence of 0.80 and 0.53%, respectively, in accordance with the prevalence among health care workers in Sweden; 0.68%). Liver biopsies in three of the patients showed only mild inflammation without fibrosis and in two of the other three the albumin and/or PT-INR level was normal contradicting any substantial impairment of the liver function. The low anti-HCV prevalence that we found contradicts an etio...Continue Reading

References

Apr 1, 1994·Scandinavian Journal of Gastroenterology·J StruveO Weiland
May 5, 1998·Journal of Internal Medicine·K SjöbergS Eriksson
Dec 22, 1998·The American Journal of Gastroenterology·N N Zein
Dec 22, 1998·The American Journal of Gastroenterology·A MangiaA Andriulli
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
May 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·A SotiropoulosS I Pappas
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CaroniaG J Alexander
May 10, 2000·Diabetes Research and Clinical Practice·L SangiorgioM Lunetta
Sep 20, 2000·Scandinavian Journal of Gastroenterology·G HoffmannS Lindgren
Aug 24, 2002·Epidemiologic Reviews·S H MehtaD L Thomas
May 11, 2004·Current Diabetes Reports·Gül BahtiyarSamy I McFarlane

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Citations

Mar 3, 2015·Indian Journal of Endocrinology and Metabolism·Demitrost LalooSalam Ranabir
Jan 13, 2018·Reviews in Endocrine & Metabolic Disorders·Silvia FabianiAlessandro Antonelli
Sep 4, 2015·World Journal of Gastroenterology : WJG·Tatjana Vilibic-CavlekJasmina Vranes
Feb 7, 2009·Diabetes & Metabolism·M Alaei, F Negro

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