PMID: 16648896May 2, 2006Paper

Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
L K SilvaM G Reis

Abstract

Hepatitis C virus (HCV) infection has been identified as the major cause of chronic liver disease among patients on chronic hemodialysis (HD), despite the important reduction in risks obtained by testing candidate blood donors for anti-HCV antibodies and the use of recombinant erythropoietin to treat anemia. A cross-sectional study was performed to estimate the prevalence of HCV infection and genotypes among HD patients in Salvador, Northeastern Brazil. Anti-HCV seroprevalence was determined by ELISA in 1243 HD patients from all ten different dialysis centers of the city. HCV infection was confirmed by RT-PCR and genotyping was performed by restriction fragment length polymorphism. Anti-HCV seroprevalence among HD patients was 10.5% (95% CI: 8.8-12.3) (Murex anti-HCV, Abbott Murex, Chicago, IL, USA). Blood samples for qualitative HCV detection and genotyping were collected from 125/130 seropositive HD patients (96.2%). HCV-RNA was detected in 92/125 (73.6%) of the anti-HCV-positive patients. HCV genotype 1 (77.9%) was the most prevalent, followed by genotype 3 (10.5%) and genotype 2 (4.6%). Mixed infections of genotypes 1 and 3 were found in 7.0% of the total number of patients. The present results indicate a significant decrea...Continue Reading

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Citations

May 30, 2013·Virology Journal·Naylê Maria Oliveira da SilvaAna Maria Barral de Martinez
Jul 7, 2007·Archives of Medical Research·Margarita Dehesa-Violante, Rafael Nuñez-Nateras
May 29, 2009·Journal of Medical Virology·Laura Patrícia Viana MaiaAdriana Malheiro
Jul 16, 2013·Journal of Medical Virology·Maria de Jesus Rodrigues de FreitasLuisa Caricio Martins
May 25, 2010·Hemodialysis International·Seyed-Moayed AlavianMasoud Ahmadzad-Asl
Oct 22, 2010·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Bruno GalperimNilo Ikuta
Oct 24, 2008·American Journal of Infection Control·Franck LaporteJacques Izopet
Dec 23, 2009·Memórias do Instituto Oswaldo Cruz·Alexandre Martins Portelinha FilhoLuiz Euribel Prestes-Carneiro
Jun 1, 2010·Memórias do Instituto Oswaldo Cruz·Maria Betânia S SilvaMitermayer G Reis
Dec 7, 2007·Memórias do Instituto Oswaldo Cruz·Cláudia Maria Dornelles da SilvaMaria Lucia Rosa Rossetti
Jun 20, 2007·Hemodialysis International·Ayman Karkar
Jan 1, 2015·Journal of Translational Internal Medicine·Bassam Bernieh
Jan 21, 2017·World Journal of Gastroenterology : WJG·Soheil Ashkani-EsfahaniMohammad Salehi-Marzijarani
Dec 17, 2010·World Journal of Hepatology·Ganesh Kumar AnbazhaganThirunalasundari Thiyagarajan
Jun 4, 2010·Arquivos De Gastroenterologia·José Rafael LeãoJulio Maria Fonseca Chebli
Jan 12, 2010·Indian Journal of Medical Microbiology·F FarshadpourM A Jalalifar

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