Prevalence of hepatitis C virus infections and distribution of hepatitis C virus genotypes among Korean blood donors.

Annals of Laboratory Medicine
Deok Ja OhJa Young Lee

Abstract

Hepatitis C virus (HCV) remains a worldwide health-care burden. Prevalence rates vary and the distribution of genotypes depends on geographical location. Here, the recent prevalence of HCV infections and distribution of HCV genotypes among Korean blood donors were studied. Between February 2005 and December 2009, a total of 11,064,532 donors were screened for anti-HCV and 11,412,690 donors were screened for HCV RNA. HCV genotyping was conducted for 748 blood donors with HCV RNA by using the line probe assay (VERSANT HCV Genotype 2.0 Assay, Bayer Healthcare, USA) after amplification of the 5'-untranslated and core regions of the genome. The anti-HCV prevalence was 0.16% (17,250/11,064,532). HCV RNA was detected in 959 out of the 11,412,690 donors (8.4/100,000). HCV RNA was more prevalent among women, donors who resided at harbor sites, and first-time donors. In addition, the prevalence of HCV RNA increased with age. The genotypes of 740 out of the 748 tested donors (98.9%) were identified. HCV genotype 1b (47.7%) and 2a/2c (35.0%) were dominant. Genotypes 2 (7.6%), 2b (2.3%), 3a (1.6%), 1a (1.3%), 1 (0.9%), 2v (0.5%), 1v (0.1%), and 3 (0.1%) were also identified. Genotype 4a/4c/4d (0.1%) was detected for the first time in one Ko...Continue Reading

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Citations

Mar 25, 2010·Virology Journal·Sayyed H Zarkesh-EsfahaniMasoud Edalati
Mar 25, 2014·World Journal of Gastroenterology : WJG·Vo Duy ThongYong Poovorawan
Jan 30, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Do Young KimMoran Ki
Jan 11, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Eleonora Grassi, Alessio Aghemo
Jan 1, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Sebastián Marciano, Adrián C Gadano
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Apr 18, 2013·Clinical and Molecular Hepatology·Mun Hyuk SeongKisang Kim
Jul 4, 2013·Southern Medical Journal·Mary Jane BurtonStephen A Geraci

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Methods Mentioned

BETA
nucleic acid amplification
genotyping
electrophoresis
PCR

Software Mentioned

VERSANT

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