Prevalence of hepatitis G virus RNA in French blood donors and recipients

Transfusion
P LoiseauJ J Lefrère

Abstract

Recently, cases of chronic hepatitis were linked to the presence of genomic sequences of a newly described RNA virus termed hepatitis G virus (HGV) and belonging to the Flaviviridae family. The presence of HGV RNA was searched for by polymerase chain reaction in a population of blood donors and in patients who had received multiple blood component transfusions and/or intravenous immunoglobulin (IVIG) infusions. Twenty-one (4.2%) of 500 donors were positive for HGV RNA as were 21 (10.7%) of 196 nonimmunosuppressed patients who had received multiple transfusions of packed red cells, 4 (8.7%) of 46 common variable immune deficiency (CVID) patients who had received only IVIG, and 22 (24.7%) of 89 bone marrow transplant (BMT) patients who had received IVIG and cellular components. The proportion of HGV-positive individuals was significantly higher in the immunosuppressed recipients (CVID and BMT patients) than in the nonimmunosuppressed patients who were multiply transfused with packed red cells (p < 0.03). The proportion of HGV-positive individuals was significantly higher in the BMT patients who had received IVIG and cellular components than in the CVID patients who had received IVIG only (p < 0.03). Eight (17.0%) of the 47 HGV-po...Continue Reading

Citations

Sep 24, 1998·Blood Reviews·P Simmonds
Jul 26, 2003·Transfusion Medicine Reviews·Eleftherios C Vamvakas
May 5, 1998·Transfusion Medicine Reviews·K G Hadlock, S K Foung
Dec 22, 1999·Journal of Viral Hepatitis·A LöveA Widell
Mar 23, 2012·The Journal of Infectious Diseases·Farnaz VahidniaB Custer
Jul 12, 2002·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Giovanni LodiJoel B Epstein
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Hans-Gert HeuftRainer Blasczyk
Oct 3, 2006·Current Opinion in Anaesthesiology·F F WagnerB Kubanek
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jeffrey S Barrett
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J D CollierJ Heathcote
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LamorilY Nordmann
May 4, 2004·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P MerleC Trépo
Apr 20, 2001·Journal of Maxillofacial Surgery·Maria ChristopoulouIoannis Iatrou
Jul 11, 1998·Lancet·L A SelveyE J Gowans
Nov 27, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·M RobaczewskaB Falkiewicz
Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P. ClevenbergP. Dellamonica
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J F DesassisA M Couroucé
Jul 6, 2000·Journal of Clinical Microbiology·S A NordbøA B Dalen

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