Prevalence of herpes simplex virus type 1 glycoprotein G (gG) and gI genotypes in patients with different herpetic diseases during the last four decades

Journal of Medical Virology
A SauerbreiPeter Wutzler

Abstract

The objective of this study was to genotype 375 clinical herpes simplex virus type 1 (HSV-1) isolates collected from the German Reference Laboratory of HSV and VZV between 1973 and 2010. The method is based on the amplification and the restriction fragment length polymorphism analysis of the glycoprotein G (gG) and gI. 45.1% of isolates were classified as genotype A, 28.5% as B, and 4.3% as C. 22.1% presented different cleavage patterns for gG and gI suggesting intergenic recombinants A/B in 7.7%, A/C in 0.5%, B/A in 9.3%, B/C in 1.9%, C/A in 1.6%, and C/B in 0.5% of isolates. Two isolates from 1982 and 2010 presented atypical gI cleavage pattern consistent with novel intragenic recombination between genotypes A and C. There were no significant differences of the prevalence of genotypes A, B as well as the recombinants A/B, B/A dependent on the age/gender of patients and the time period in which the strains were isolated. Likewise, there were no significant differences in the distribution of the genotypes A and B as etiological agents of eczema herpeticum, herpes labialis, herpes genitalis, and herpetic gingivostomatitis. The number of recombinants was not different significantly in the groups of the distinct herpetic diseases....Continue Reading

References

May 26, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rory BowdenRyk Ward
Oct 13, 2006·Journal of Clinical Microbiology·Peter NorbergJan-Ake Liljeqvist
Oct 24, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Luciano Marques-SilvaRicardo Santiago Gomez
Feb 3, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jonas Schmidt-ChanasitHans Wilhelm Doerr
Feb 17, 2009·The Journal of General Virology·Jan Åke LiljeqvistPeter Norberg
Sep 24, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Peter Norberg
Apr 27, 2010·Journal of Medical Virology·Sarah DambrosiGuy Boivin
Apr 13, 2011·Current Opinion in Neurology·Israel Steiner

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Citations

Aug 19, 2015·Archives of Virology·Brigitte GlückAndreas Sauerbrei
Aug 26, 2016·The Journal of General Virology·Florian PfaffRoland Zell

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